Typhoid fever. An epidemic with remarkably few clinical signs and symptoms

Stephen A Klotz, J. H. Jorgensen, F. J. Buckwold, P. C. Craven

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A major common-source, foodborne epidemic of typhoid fever occurred in San Antonio, Tex, in the fall of 1981, involving 80 verified cases. We summarize the clinical course of our 34 patients who had a nonspecific symptom complex that included at the initial examination fever (32 patients, 93%), headache (19 patients, 57%), diarrhea (11 patients, 33%), and anorexia (ten patients, 30%). The most common initial diagnoses were urinary tract and upper respiratory tract infections. The subsequent isolation of Salmonella typhi from blood cultures was usually unexpected. Physical findings were different from two previous series originating in the United States. Hepatomegaly was noted in only 7% (two patients), splenomegaly was noted in 13% (four patients), and rose spots were noted in 5% (two patients) of the patients. Liver function tests results, however, were abnormal in 32 (95%) of the 34 patients (mean SGOT, 155 IU/mL). Typhoid fever, as seen in this outbreak, was notable for its nonspecific and mild manifestation and uniformly favorable outcome.

Original languageEnglish (US)
Pages (from-to)533-537
Number of pages5
JournalArchives of Internal Medicine
Volume144
Issue number3
DOIs
StatePublished - 1984
Externally publishedYes

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Typhoid Fever
Signs and Symptoms
Salmonella typhi
Hepatomegaly
Liver Function Tests
Splenomegaly
Anorexia
Aspartate Aminotransferases
Urinary Tract
Respiratory Tract Infections
Disease Outbreaks
Headache
Diarrhea
Fever

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Typhoid fever. An epidemic with remarkably few clinical signs and symptoms. / Klotz, Stephen A; Jorgensen, J. H.; Buckwold, F. J.; Craven, P. C.

In: Archives of Internal Medicine, Vol. 144, No. 3, 1984, p. 533-537.

Research output: Contribution to journalArticle

Klotz, Stephen A ; Jorgensen, J. H. ; Buckwold, F. J. ; Craven, P. C. / Typhoid fever. An epidemic with remarkably few clinical signs and symptoms. In: Archives of Internal Medicine. 1984 ; Vol. 144, No. 3. pp. 533-537.
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