Tyrosine-hydroxylase-containing neurons in the primate basal forebrain magnocellular complex

Gunnar K. Gouras, Naomi E Rance, W. Scott Young, Vassilis E. Koliatsos

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Immunocytochemistry and in situ hybridization for tyrosine hydroxylase (TH) were used to study the distribution of putative catecholaminergic neurons in the basal forebrain magnocellular complex (BFMC) of monkeys and humans. Magnocellular TH-expressing neurons in the primate BFMC are distributed along a rostrocaudal gradient, with the largest proportion of these cells located in the medial septal nucleus and nucleus of the diagonal band of Broca; smaller TH-containing neurons generally follow the same distribution. These findings suggest that, within rostromedial segments of the BFMC, there is a distinct subpopulation of neurons that express catecholamine-synthesizing enzymes. Further research is necessary to establish whether these neurons utilize one or more catecholamines as neurotransmitters.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalBrain Research
Volume584
Issue number1-2
DOIs
StatePublished - Jul 3 1992

Fingerprint

Tyrosine 3-Monooxygenase
Primates
Neurons
Septal Nuclei
Catecholamines
Diagonal Band of Broca
Haplorhini
In Situ Hybridization
Neurotransmitter Agents
Immunohistochemistry
Basal Forebrain
Enzymes
Research

Keywords

  • Catecholaminergic
  • Diagonal band
  • Human
  • Monkey
  • Nucleus basalis
  • Septum

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Tyrosine-hydroxylase-containing neurons in the primate basal forebrain magnocellular complex. / Gouras, Gunnar K.; Rance, Naomi E; Scott Young, W.; Koliatsos, Vassilis E.

In: Brain Research, Vol. 584, No. 1-2, 03.07.1992, p. 287-293.

Research output: Contribution to journalArticle

Gouras, Gunnar K. ; Rance, Naomi E ; Scott Young, W. ; Koliatsos, Vassilis E. / Tyrosine-hydroxylase-containing neurons in the primate basal forebrain magnocellular complex. In: Brain Research. 1992 ; Vol. 584, No. 1-2. pp. 287-293.
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