Ubiquitin-specific peptidase 22 functions and its involvement in disease

Johanna Melo-Cardenas, Yusi Zhang, Donna D. Zhang, Deyu Fang

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Deubiquitylases remove ubiquitin moieties from different substrates to regulate protein activity and cell homeostasis. Since this posttranslational modification plays a role in several different cellular functions, its deregulation has been associated with different pathologies. Aberrant expression of the Ubiquitin-Specific Peptidase 22 (USP22) has been associated with poor cancer prognosis and neurological disorders. However, little is known about USP22 role in these pathologies or in normal physiology. This review summarizes the current knowledge about USP22 function from yeast to human and provides an overview of the possible mechanisms by which USP22 is emerging as a potential oncogene.

Original languageEnglish (US)
Pages (from-to)44848-44856
Number of pages9
JournalOncotarget
Volume7
Issue number28
DOIs
StatePublished - 2016

Keywords

  • Ataxia
  • Cancer
  • Deubiquitylation
  • Oncogene
  • USP22

ASJC Scopus subject areas

  • Oncology

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