Ugi/Aldol sequence: Expeditious entry to several families of densely substituted nitrogen heterocycles

Zhigang Xu, Fabio De Moliner, Alexandra P. Cappelli, Christopher Hulme

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

Complexity from simplicity: Nitrogen-containing heterocycles have been assembled by means of unprecedented domino processes designed to take advantage of diversity assembly using strategically decorated Ugi products (see scheme). The aldol reaction is the second common denominator which enables sequences of up to five steps in one pot, thus producing unique molecular architectures in rapid fashion.

Original languageEnglish (US)
Pages (from-to)8037-8040
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number32
DOIs
StatePublished - Aug 6 2012

Keywords

  • aldol reaction
  • molecular diversity
  • multicomponent reactions
  • nitrogen heterocycles
  • synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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