Ultrasonographic detection of testicular ischemia in a canine model using phospholipid coated microbubbles (MRX-115)

Catherine Metzger-Rose, Elizabeth A. Krupinski, William H. Wright, Michael R. Baker, Thomas P. McCreery, Terrence R. Barrette, Evan C. Unger

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The purpose of this study was to determine if the sonographic contrast agent MRX-115 could improve the accuracy of Doppler ultrasonographic diagnosis of testicular ischemia. Testicular duplex ultrasonography was performed on six dogs before and after surgical ligation of the testicular artery, and before and after intravenous injection of MRX-115. Six radiologists blinded to experimental conditions rated the testicular blood flow. Receiver operating characteristics curves for conditions with and without administration of contrast agent were compared using Student's t-test for paired observations. Statistically significant differences were found both for the testes viewed individually (P = 0.003) and for the testes in comparison to the contralateral side (P = 0.0001). MRX-115 therefore is found to improve duplex sonographic evaluation of testicular ischemia.

Original languageEnglish (US)
Pages (from-to)317-324
Number of pages8
JournalJournal of Ultrasound in Medicine
Volume16
Issue number5
StatePublished - May 1997

Keywords

  • Contrast media
  • Dogs
  • Microbubbles
  • Testicular
  • Testis
  • Torsion
  • Ultrasonography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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