Ultrasound attenuation of the calcaneus: A sensitive and specific discriminator of osteopenia in postmenopausal women

Mats Agren, Andrew Karellas, Daniel Leahey, Sandy Marks, Daniel Baran

Research output: Contribution to journalArticle

132 Scopus citations

Abstract

Recent studies have evaluated techniques for estimating bone mass without radiation. The present study compares broadband ultrasound attenuation of the calcaneus and bone densities of the femoral neck and the lumbar spine in 17 normal women and 41 women with osteoporosis. Twenty of the osteoporotic women had spine (n=16) or femoral neck (n=4) fractures. There was a significant decrease in the broadband ultrasound attenuation (P<0.001) in women with osteoporosis compared with normal women. The osteoporotic women also showed a decrease in vertebral (P<0.0001) and femoral neck (P<0.0001) densities compared with normal women. At 63 dB/MHz, the sensitivity and specificity of broadband ultrasound attenuation for decreased bone mineral density with or without fractures were 76%. All women with fractures had a broadband ultrasound attenuation less than 72 dB/MHz. This corresponded to a specificity of 41%. To determine whether broadband ultrasound attenuation correlated with trabecular bone volume, samples of cadaver calcaneus were analyzed. The histologic determination showed a significant correlation between broadband ultrasound attenuation and trabecular bone volume (r=0.992, P=0.008). These results suggest broadband ultrasound attenuation of the calcaneus reflects bone mass and can be used as a safe and sensitive indicator for decreased axial bone density.

Original languageEnglish (US)
Pages (from-to)240-244
Number of pages5
JournalCalcified Tissue International
Volume48
Issue number4
DOIs
StatePublished - Apr 1 1991
Externally publishedYes

Keywords

  • Bone density
  • Osteoporosis
  • Ultrasound

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

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