Ultrasound current source density imaging of a time-varying current field in a multielectrode nerve chamber

Ragnar Olafsson, Qian Li, Zhaohui Wang, Pier Ingram, Russell S Witte

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Drug resistant epilepsy can in some cases be treated with surgery. To minimize potentially crippling side effects of surgery, a detailed functional map of the brain is usually required prior to resection. Conventional mapping techniques rely on a coarse grid of electrodes with limited spatial resolution. Ultrasound Current Source Density Imaging (UCSDI) is new high resolution method to image electric current based on ultrasound. UCSDI potentially enhances conventional mapping procedures as it produces 4D (space and time) maps of current flow co-registered to ultrasound. In this paper, we describe a new system for studying UCSDI in peripheral nerves and neural tissue. This system allows multi-electrode detection of conventional electrophysiological signals simultaneous with UCSDI. UCSDI was used to map short bursts of current injected through the rat sciatic nerve. The amplitude of the current was varied to test the sensitivity of the system. The detection threshold was 0.1 mA/cm2 at ∼250 kPa, well within range for detecting bioelectric signals in neural tissue.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE Ultrasonics Symposium
DOIs
StatePublished - 2009
Event2009 IEEE International Ultrasonics Symposium, IUS 2009 - Rome, Italy
Duration: Sep 20 2009Sep 23 2009

Other

Other2009 IEEE International Ultrasonics Symposium, IUS 2009
CountryItaly
CityRome
Period9/20/099/23/09

Fingerprint

nerves
chambers
surgery
epilepsy
electrodes
electric current
rats
brain
bursts
drugs
spatial resolution
grids
thresholds
sensitivity
high resolution

Keywords

  • Acoustoelectric
  • Bioelectromagnetism
  • Electrical brain mapping
  • Epilepsy
  • Neuroelectrophysiology
  • UCSDI

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Ultrasound current source density imaging of a time-varying current field in a multielectrode nerve chamber. / Olafsson, Ragnar; Li, Qian; Wang, Zhaohui; Ingram, Pier; Witte, Russell S.

Proceedings - IEEE Ultrasonics Symposium. 2009. 5441400.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Olafsson, R, Li, Q, Wang, Z, Ingram, P & Witte, RS 2009, Ultrasound current source density imaging of a time-varying current field in a multielectrode nerve chamber. in Proceedings - IEEE Ultrasonics Symposium., 5441400, 2009 IEEE International Ultrasonics Symposium, IUS 2009, Rome, Italy, 9/20/09. https://doi.org/10.1109/ULTSYM.2009.5441400
Olafsson, Ragnar ; Li, Qian ; Wang, Zhaohui ; Ingram, Pier ; Witte, Russell S. / Ultrasound current source density imaging of a time-varying current field in a multielectrode nerve chamber. Proceedings - IEEE Ultrasonics Symposium. 2009.
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