# Ultrasound current source density imaging of the cardiac activation wave using a clinical cardiac catheter

Yexian Qin, Qian Li, Pier Ingram, Christy Barber, Zhonglin Liu, Russell S Witte

Research output: Contribution to journalArticle

9 Citations (Scopus)

### Abstract

Ultrasound current source density imaging (UCSDI), based on the acoustoelectric (AE) effect, is a noninvasive method for mapping electrical current in 4-D (space + time). This technique potentially overcomes limitations with conventional electrical mapping procedures typically used during treatment of sustained arrhythmias. However, the weak AE signal associated with the electrocardiogram is a major challenge for advancing this technology. In this study, we examined the effects of the electrode configuration and ultrasound frequency on the magnitude of the AE signal and quality of UCSDI using a rabbit Langendorff heart preparation. The AE signal was much stronger at 0.5 MHz (2.99 $\mu$V/MPa) than 1.0 MHz (0.42 $\mu$V/MPa). Also, a clinical lasso catheter placed on the epicardium exhibited excellent sensitivity without penetrating the tissue. We also present, for the first time, 3-D cardiac activation maps of the live rabbit heart using only one pair of recording electrodes. Activation maps were used to calculate the cardiac conduction velocity for atrial (1.31 m/s) and apical (0.67 m/s) pacing. This study demonstrated that UCSDI is potentially capable of real-time 3-D cardiac activation wave mapping, which would greatly facilitate ablation procedures for treatment of arrhythmias.

Original language English (US) 6873233 241-247 7 IEEE Transactions on Biomedical Engineering 62 1 https://doi.org/10.1109/TBME.2014.2345771 Published - Jan 1 2015

### Fingerprint

Catheters
Ultrasonics
Chemical activation
Imaging techniques
Acoustoelectric effects
Electrodes
Ablation
Electrocardiography
Tissue

### ASJC Scopus subject areas

• Biomedical Engineering

### Cite this

Ultrasound current source density imaging of the cardiac activation wave using a clinical cardiac catheter. / Qin, Yexian; Li, Qian; Ingram, Pier; Barber, Christy; Liu, Zhonglin; Witte, Russell S.

In: IEEE Transactions on Biomedical Engineering, Vol. 62, No. 1, 6873233, 01.01.2015, p. 241-247.

Research output: Contribution to journalArticle

@article{31702a6f3d4044099210f5247f560fa1,
title = "Ultrasound current source density imaging of the cardiac activation wave using a clinical cardiac catheter",
abstract = "Ultrasound current source density imaging (UCSDI), based on the acoustoelectric (AE) effect, is a noninvasive method for mapping electrical current in 4-D (space + time). This technique potentially overcomes limitations with conventional electrical mapping procedures typically used during treatment of sustained arrhythmias. However, the weak AE signal associated with the electrocardiogram is a major challenge for advancing this technology. In this study, we examined the effects of the electrode configuration and ultrasound frequency on the magnitude of the AE signal and quality of UCSDI using a rabbit Langendorff heart preparation. The AE signal was much stronger at 0.5 MHz (2.99 $\mu$V/MPa) than 1.0 MHz (0.42 $\mu$V/MPa). Also, a clinical lasso catheter placed on the epicardium exhibited excellent sensitivity without penetrating the tissue. We also present, for the first time, 3-D cardiac activation maps of the live rabbit heart using only one pair of recording electrodes. Activation maps were used to calculate the cardiac conduction velocity for atrial (1.31 m/s) and apical (0.67 m/s) pacing. This study demonstrated that UCSDI is potentially capable of real-time 3-D cardiac activation wave mapping, which would greatly facilitate ablation procedures for treatment of arrhythmias.",
author = "Yexian Qin and Qian Li and Pier Ingram and Christy Barber and Zhonglin Liu and Witte, {Russell S}",
year = "2015",
month = "1",
day = "1",
doi = "10.1109/TBME.2014.2345771",
language = "English (US)",
volume = "62",
pages = "241--247",
journal = "IEEE Transactions on Biomedical Engineering",
issn = "0018-9294",
publisher = "IEEE Computer Society",
number = "1",

}

TY - JOUR

T1 - Ultrasound current source density imaging of the cardiac activation wave using a clinical cardiac catheter

AU - Qin, Yexian

AU - Li, Qian

AU - Ingram, Pier

AU - Barber, Christy

AU - Liu, Zhonglin

AU - Witte, Russell S

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Ultrasound current source density imaging (UCSDI), based on the acoustoelectric (AE) effect, is a noninvasive method for mapping electrical current in 4-D (space + time). This technique potentially overcomes limitations with conventional electrical mapping procedures typically used during treatment of sustained arrhythmias. However, the weak AE signal associated with the electrocardiogram is a major challenge for advancing this technology. In this study, we examined the effects of the electrode configuration and ultrasound frequency on the magnitude of the AE signal and quality of UCSDI using a rabbit Langendorff heart preparation. The AE signal was much stronger at 0.5 MHz (2.99 $\mu$V/MPa) than 1.0 MHz (0.42 $\mu$V/MPa). Also, a clinical lasso catheter placed on the epicardium exhibited excellent sensitivity without penetrating the tissue. We also present, for the first time, 3-D cardiac activation maps of the live rabbit heart using only one pair of recording electrodes. Activation maps were used to calculate the cardiac conduction velocity for atrial (1.31 m/s) and apical (0.67 m/s) pacing. This study demonstrated that UCSDI is potentially capable of real-time 3-D cardiac activation wave mapping, which would greatly facilitate ablation procedures for treatment of arrhythmias.

AB - Ultrasound current source density imaging (UCSDI), based on the acoustoelectric (AE) effect, is a noninvasive method for mapping electrical current in 4-D (space + time). This technique potentially overcomes limitations with conventional electrical mapping procedures typically used during treatment of sustained arrhythmias. However, the weak AE signal associated with the electrocardiogram is a major challenge for advancing this technology. In this study, we examined the effects of the electrode configuration and ultrasound frequency on the magnitude of the AE signal and quality of UCSDI using a rabbit Langendorff heart preparation. The AE signal was much stronger at 0.5 MHz (2.99 $\mu$V/MPa) than 1.0 MHz (0.42 $\mu$V/MPa). Also, a clinical lasso catheter placed on the epicardium exhibited excellent sensitivity without penetrating the tissue. We also present, for the first time, 3-D cardiac activation maps of the live rabbit heart using only one pair of recording electrodes. Activation maps were used to calculate the cardiac conduction velocity for atrial (1.31 m/s) and apical (0.67 m/s) pacing. This study demonstrated that UCSDI is potentially capable of real-time 3-D cardiac activation wave mapping, which would greatly facilitate ablation procedures for treatment of arrhythmias.

UR - http://www.scopus.com/inward/record.url?scp=84919919325&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919919325&partnerID=8YFLogxK

U2 - 10.1109/TBME.2014.2345771

DO - 10.1109/TBME.2014.2345771

M3 - Article

VL - 62

SP - 241

EP - 247

JO - IEEE Transactions on Biomedical Engineering

JF - IEEE Transactions on Biomedical Engineering

SN - 0018-9294

IS - 1

M1 - 6873233

ER -