Ultrasound-induced sonoporation with the aid of magnetic nanoparticles

Pavlos Anastasiadis, John S. Allen, Terry Matsunaga, Joachim Bertram, Peter K. Weber, Stefan Moisyadi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Targeted gene and drug delivery has untapped potential for the treatment of a wide range of pathological conditions. The recent advancements in ultrasound contrast agents (UCAs) including their ability to target regions of interest (ROI) with high specificity makes them ideal for a range of both in vitro and in vivo studies. This work investigates gene expression enhancement by a novel combination of nanosized magnetic particles (MagTag®) and cationic UCAs (cUCAs). The cUCAs have been studied alone and in combination with the MATra-A reagent (Iba Life Sciences, Goettingen, Germany), that uses activated magnetic fields for the delivery of nucleic acids into the cell nucleus.

Original languageEnglish (US)
Title of host publication2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages2052-2054
Number of pages3
DOIs
StatePublished - Dec 1 2012
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: Oct 7 2012Oct 10 2012

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2012 IEEE International Ultrasonics Symposium, IUS 2012
CountryGermany
CityDresden
Period10/7/1210/10/12

Keywords

  • gene delivery
  • magnetic-assisted transfection
  • piggyBac plasmid
  • sonoporation
  • ultrasound contrast agents

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Fingerprint Dive into the research topics of 'Ultrasound-induced sonoporation with the aid of magnetic nanoparticles'. Together they form a unique fingerprint.

  • Cite this

    Anastasiadis, P., Allen, J. S., Matsunaga, T., Bertram, J., Weber, P. K., & Moisyadi, S. (2012). Ultrasound-induced sonoporation with the aid of magnetic nanoparticles. In 2012 IEEE International Ultrasonics Symposium, IUS 2012 (pp. 2052-2054). [6562554] (IEEE International Ultrasonics Symposium, IUS). https://doi.org/10.1109/ULTSYM.2012.0513