Ultrasound-induced sonoporation with the aid of magnetic nanoparticles

Pavlos Anastasiadis, John S. Allen, Terry O Matsunaga, Joachim Bertram, Peter K. Weber, Stefan Moisyadi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Targeted gene and drug delivery has untapped potential for the treatment of a wide range of pathological conditions. The recent advancements in ultrasound contrast agents (UCAs) including their ability to target regions of interest (ROI) with high specificity makes them ideal for a range of both in vitro and in vivo studies. This work investigates gene expression enhancement by a novel combination of nanosized magnetic particles (MagTag®) and cationic UCAs (cUCAs). The cUCAs have been studied alone and in combination with the MATra-A reagent (Iba Life Sciences, Goettingen, Germany), that uses activated magnetic fields for the delivery of nucleic acids into the cell nucleus.

Original languageEnglish (US)
Title of host publicationIEEE International Ultrasonics Symposium, IUS
Pages2052-2054
Number of pages3
DOIs
StatePublished - 2012
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: Oct 7 2012Oct 10 2012

Other

Other2012 IEEE International Ultrasonics Symposium, IUS 2012
CountryGermany
CityDresden
Period10/7/1210/10/12

Fingerprint

delivery
nanoparticles
life sciences
gene expression
nucleic acids
Germany
genes
reagents
drugs
nuclei
augmentation
magnetic fields

Keywords

  • gene delivery
  • magnetic-assisted transfection
  • piggyBac plasmid
  • sonoporation
  • ultrasound contrast agents

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Anastasiadis, P., Allen, J. S., Matsunaga, T. O., Bertram, J., Weber, P. K., & Moisyadi, S. (2012). Ultrasound-induced sonoporation with the aid of magnetic nanoparticles. In IEEE International Ultrasonics Symposium, IUS (pp. 2052-2054). [6562554] https://doi.org/10.1109/ULTSYM.2012.0513

Ultrasound-induced sonoporation with the aid of magnetic nanoparticles. / Anastasiadis, Pavlos; Allen, John S.; Matsunaga, Terry O; Bertram, Joachim; Weber, Peter K.; Moisyadi, Stefan.

IEEE International Ultrasonics Symposium, IUS. 2012. p. 2052-2054 6562554.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Anastasiadis, P, Allen, JS, Matsunaga, TO, Bertram, J, Weber, PK & Moisyadi, S 2012, Ultrasound-induced sonoporation with the aid of magnetic nanoparticles. in IEEE International Ultrasonics Symposium, IUS., 6562554, pp. 2052-2054, 2012 IEEE International Ultrasonics Symposium, IUS 2012, Dresden, Germany, 10/7/12. https://doi.org/10.1109/ULTSYM.2012.0513
Anastasiadis P, Allen JS, Matsunaga TO, Bertram J, Weber PK, Moisyadi S. Ultrasound-induced sonoporation with the aid of magnetic nanoparticles. In IEEE International Ultrasonics Symposium, IUS. 2012. p. 2052-2054. 6562554 https://doi.org/10.1109/ULTSYM.2012.0513
Anastasiadis, Pavlos ; Allen, John S. ; Matsunaga, Terry O ; Bertram, Joachim ; Weber, Peter K. ; Moisyadi, Stefan. / Ultrasound-induced sonoporation with the aid of magnetic nanoparticles. IEEE International Ultrasonics Symposium, IUS. 2012. pp. 2052-2054
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