Ultrasound molecular imaging with customizable nanoscale phase-change contrast agents: An in-vitro feasibility study

Paul S. Sheeran, Jason E. Streeter, Lee Mullin, Terry O. Matsunaga, Paul A. Dayton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Phase-change contrast agents (PCCAs) can be vaporized to the echogenic gas state by acoustic/thermal energy from an ultrasound transducer. Few studies to date have explored the molecular imaging capability of PCCAs. In this study, we generate nanoscale droplets composed of low boiling point perfluorocarbons encapsulated in lipid shells capable of targeting αvβ 3. When incubated with HUVEC cells expressing α vβ3, the agents could be activated and imaged with the same transducer, and produced a significant increase in pixel intensity within the cell monolayer. Analysis showed a significant imaging contrast over both baseline and non-targeted controls. Low-boiling point, nanoscale PCCAs may provide new approaches to intravascular and extravascular ultrasound-based molecular imaging.

Original languageEnglish (US)
Title of host publication2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages2309-2312
Number of pages4
DOIs
StatePublished - Dec 1 2012
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: Oct 7 2012Oct 10 2012

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2012 IEEE International Ultrasonics Symposium, IUS 2012
CountryGermany
CityDresden
Period10/7/1210/10/12

Keywords

  • acoustic droplet vaporization
  • contrast agent
  • molecular imaging
  • perfluorocarbon
  • phase-change

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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    Sheeran, P. S., Streeter, J. E., Mullin, L., Matsunaga, T. O., & Dayton, P. A. (2012). Ultrasound molecular imaging with customizable nanoscale phase-change contrast agents: An in-vitro feasibility study. In 2012 IEEE International Ultrasonics Symposium, IUS 2012 (pp. 2309-2312). [6561899] (IEEE International Ultrasonics Symposium, IUS). https://doi.org/10.1109/ULTSYM.2012.0577