Ultrasound molecular imaging with customizable nanoscale phase-change contrast agents

An in-vitro feasibility study

Paul S. Sheeran, Jason E. Streeter, Lee Mullin, Terry O Matsunaga, Paul A. Dayton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Phase-change contrast agents (PCCAs) can be vaporized to the echogenic gas state by acoustic/thermal energy from an ultrasound transducer. Few studies to date have explored the molecular imaging capability of PCCAs. In this study, we generate nanoscale droplets composed of low boiling point perfluorocarbons encapsulated in lipid shells capable of targeting αvβ 3. When incubated with HUVEC cells expressing α vβ3, the agents could be activated and imaged with the same transducer, and produced a significant increase in pixel intensity within the cell monolayer. Analysis showed a significant imaging contrast over both baseline and non-targeted controls. Low-boiling point, nanoscale PCCAs may provide new approaches to intravascular and extravascular ultrasound-based molecular imaging.

Original languageEnglish (US)
Title of host publicationIEEE International Ultrasonics Symposium, IUS
Pages2309-2312
Number of pages4
DOIs
StatePublished - 2012
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: Oct 7 2012Oct 10 2012

Other

Other2012 IEEE International Ultrasonics Symposium, IUS 2012
CountryGermany
CityDresden
Period10/7/1210/10/12

Fingerprint

boiling
transducers
thermal energy
lipids
pixels
acoustics
cells
gases

Keywords

  • acoustic droplet vaporization
  • contrast agent
  • molecular imaging
  • perfluorocarbon
  • phase-change

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Sheeran, P. S., Streeter, J. E., Mullin, L., Matsunaga, T. O., & Dayton, P. A. (2012). Ultrasound molecular imaging with customizable nanoscale phase-change contrast agents: An in-vitro feasibility study. In IEEE International Ultrasonics Symposium, IUS (pp. 2309-2312). [6561899] https://doi.org/10.1109/ULTSYM.2012.0577

Ultrasound molecular imaging with customizable nanoscale phase-change contrast agents : An in-vitro feasibility study. / Sheeran, Paul S.; Streeter, Jason E.; Mullin, Lee; Matsunaga, Terry O; Dayton, Paul A.

IEEE International Ultrasonics Symposium, IUS. 2012. p. 2309-2312 6561899.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sheeran, PS, Streeter, JE, Mullin, L, Matsunaga, TO & Dayton, PA 2012, Ultrasound molecular imaging with customizable nanoscale phase-change contrast agents: An in-vitro feasibility study. in IEEE International Ultrasonics Symposium, IUS., 6561899, pp. 2309-2312, 2012 IEEE International Ultrasonics Symposium, IUS 2012, Dresden, Germany, 10/7/12. https://doi.org/10.1109/ULTSYM.2012.0577
Sheeran PS, Streeter JE, Mullin L, Matsunaga TO, Dayton PA. Ultrasound molecular imaging with customizable nanoscale phase-change contrast agents: An in-vitro feasibility study. In IEEE International Ultrasonics Symposium, IUS. 2012. p. 2309-2312. 6561899 https://doi.org/10.1109/ULTSYM.2012.0577
Sheeran, Paul S. ; Streeter, Jason E. ; Mullin, Lee ; Matsunaga, Terry O ; Dayton, Paul A. / Ultrasound molecular imaging with customizable nanoscale phase-change contrast agents : An in-vitro feasibility study. IEEE International Ultrasonics Symposium, IUS. 2012. pp. 2309-2312
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