Umbilical cord blood: A unique source of pluripotent stem cells for regenerative medicine

David T. Harris, Ian Rogers

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

It is estimated that almost 1 in 3 individuals in the United States might benefit from regenerative medecine therapy. Unfortunately, embryonic stem (ES) cell therapies are currently limited by ethical, political, biological and regulatory hurdles. Thus, for the foreseeable future, the march of regenerative medicine to the clinic will depend upon the development of non-ES cell therapies. Current sources of non-ES cells easily available in large numbers can be found in the bone marrow, adipose tissue and umbilical cord blood. Each of these types of stem cells has already begun to be utilized to treat a variety of diseases. This review will show that cord blood (CB) contains multiple populations of ES-like and other pluripotential stem cells, capable of giving rise to hematopoietic, epithelial, endothelial, and neural tissues both in vitro and in vivo. Cumulatively, the identification and isolation of these populations of pluripotent stem cells within cord blood represents a scientific breakthrough that could potentially impact every field of medicine, via their use in regenerative medicine. Thus, CB stem cells are amenable to treatment of a wide variety of diseases including cardiovascular, hepatic, ophthalmic, orthopaedic, neurological and endocrine diseases.

Original languageEnglish (US)
Pages (from-to)301-309
Number of pages9
JournalCurrent Stem Cell Research and Therapy
Volume2
Issue number4
DOIs
StatePublished - Dec 2007

Fingerprint

Pluripotent Stem Cells
Regenerative Medicine
Fetal Blood
Stem Cells
Cell- and Tissue-Based Therapy
Endocrine System Diseases
Eye Diseases
Embryonic Stem Cells
Population
Endothelium
Embryonic Development
Orthopedics
Adipose Tissue
Blood Cells
Cardiovascular Diseases
Bone Marrow
Medicine
Liver
Therapeutics

Keywords

  • Pluripotent
  • Regenerative medicine
  • Stem cells
  • Tissue engineering
  • Umbilical cord blood

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Umbilical cord blood : A unique source of pluripotent stem cells for regenerative medicine. / Harris, David T.; Rogers, Ian.

In: Current Stem Cell Research and Therapy, Vol. 2, No. 4, 12.2007, p. 301-309.

Research output: Contribution to journalArticle

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