Umbilical venous velocity pulsations are related to atrial contraction pressure waveforms in fetal lambs

Kathryn L Reed, David G. Chaffin, Caroline F. Anderson, Adam T. Newman

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: To identify the source of umbilical venous velocity pulsations, times of transmission from the atrial contraction pressure waveform to velocity waves in the inferior vena cava, ductus venosus, intra- abdominal umbilical vein, and intra-amniotic umbilical vein were examined. Methods: Five lamb fetuses at 125-135 days' gestation were instrumented with solid state pressure transducers in the inferior vena cava, fluid-filled catheters in the inferior vena cava and descending aorta, and epicardial pacemakers. Three to 5 days postoperatively, inferior vena cava, ductus venosus, and umbilical vein velocities were examined with Doppler ultrasound. Normal saline was administered until umbilical vein velocity pulsations developed (180 ± 60 mL). In three fetuses, premature atrial contractions were induced under baseline conditions and after umbilical vein velocity pulsations developed. Results: Times of transmission from the atrial contraction pressure waveform until velocity decreases in the fetal venous system were significantly different in the inferior vena cava, ductus venosus, intra-abdominal umbilical vein, and intra-amniotic umbilical vein (P < .001). Times increased with the distance from the atrium. Inferior vena cava pressure increased with fluid administration from 3.7 ± 4.7 mmHg to 9.3 ± 2.3 mmHg (P < .01). Time from increased pressure waveforms with induced premature atrial contractions to the nadir of subsequent umbilical vein velocity waves decreased from 0.123 ± 0.047 seconds before saline administration to 0.072 ± 0.039 seconds after saline administration (P < .001). Conclusion: Transmission time of atrial pressure into the venous circulation increases with distance from the atrium and decreases with volume loading. Umbilical venous velocity pulsations derive from atrial pressure changes transmitted in a retrograde fashion.

Original languageEnglish (US)
Pages (from-to)953-956
Number of pages4
JournalObstetrics and Gynecology
Volume89
Issue number6
DOIs
StatePublished - Jun 1997

Fingerprint

Umbilicus
Umbilical Veins
Atrial Pressure
Inferior Vena Cava
Atrial Premature Complexes
Fetus
Pressure Transducers
Pressure
Doppler Ultrasonography
Thoracic Aorta
Catheters
Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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Umbilical venous velocity pulsations are related to atrial contraction pressure waveforms in fetal lambs. / Reed, Kathryn L; Chaffin, David G.; Anderson, Caroline F.; Newman, Adam T.

In: Obstetrics and Gynecology, Vol. 89, No. 6, 06.1997, p. 953-956.

Research output: Contribution to journalArticle

Reed, Kathryn L ; Chaffin, David G. ; Anderson, Caroline F. ; Newman, Adam T. / Umbilical venous velocity pulsations are related to atrial contraction pressure waveforms in fetal lambs. In: Obstetrics and Gynecology. 1997 ; Vol. 89, No. 6. pp. 953-956.
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abstract = "Objective: To identify the source of umbilical venous velocity pulsations, times of transmission from the atrial contraction pressure waveform to velocity waves in the inferior vena cava, ductus venosus, intra- abdominal umbilical vein, and intra-amniotic umbilical vein were examined. Methods: Five lamb fetuses at 125-135 days' gestation were instrumented with solid state pressure transducers in the inferior vena cava, fluid-filled catheters in the inferior vena cava and descending aorta, and epicardial pacemakers. Three to 5 days postoperatively, inferior vena cava, ductus venosus, and umbilical vein velocities were examined with Doppler ultrasound. Normal saline was administered until umbilical vein velocity pulsations developed (180 ± 60 mL). In three fetuses, premature atrial contractions were induced under baseline conditions and after umbilical vein velocity pulsations developed. Results: Times of transmission from the atrial contraction pressure waveform until velocity decreases in the fetal venous system were significantly different in the inferior vena cava, ductus venosus, intra-abdominal umbilical vein, and intra-amniotic umbilical vein (P < .001). Times increased with the distance from the atrium. Inferior vena cava pressure increased with fluid administration from 3.7 ± 4.7 mmHg to 9.3 ± 2.3 mmHg (P < .01). Time from increased pressure waveforms with induced premature atrial contractions to the nadir of subsequent umbilical vein velocity waves decreased from 0.123 ± 0.047 seconds before saline administration to 0.072 ± 0.039 seconds after saline administration (P < .001). Conclusion: Transmission time of atrial pressure into the venous circulation increases with distance from the atrium and decreases with volume loading. Umbilical venous velocity pulsations derive from atrial pressure changes transmitted in a retrograde fashion.",
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N2 - Objective: To identify the source of umbilical venous velocity pulsations, times of transmission from the atrial contraction pressure waveform to velocity waves in the inferior vena cava, ductus venosus, intra- abdominal umbilical vein, and intra-amniotic umbilical vein were examined. Methods: Five lamb fetuses at 125-135 days' gestation were instrumented with solid state pressure transducers in the inferior vena cava, fluid-filled catheters in the inferior vena cava and descending aorta, and epicardial pacemakers. Three to 5 days postoperatively, inferior vena cava, ductus venosus, and umbilical vein velocities were examined with Doppler ultrasound. Normal saline was administered until umbilical vein velocity pulsations developed (180 ± 60 mL). In three fetuses, premature atrial contractions were induced under baseline conditions and after umbilical vein velocity pulsations developed. Results: Times of transmission from the atrial contraction pressure waveform until velocity decreases in the fetal venous system were significantly different in the inferior vena cava, ductus venosus, intra-abdominal umbilical vein, and intra-amniotic umbilical vein (P < .001). Times increased with the distance from the atrium. Inferior vena cava pressure increased with fluid administration from 3.7 ± 4.7 mmHg to 9.3 ± 2.3 mmHg (P < .01). Time from increased pressure waveforms with induced premature atrial contractions to the nadir of subsequent umbilical vein velocity waves decreased from 0.123 ± 0.047 seconds before saline administration to 0.072 ± 0.039 seconds after saline administration (P < .001). Conclusion: Transmission time of atrial pressure into the venous circulation increases with distance from the atrium and decreases with volume loading. Umbilical venous velocity pulsations derive from atrial pressure changes transmitted in a retrograde fashion.

AB - Objective: To identify the source of umbilical venous velocity pulsations, times of transmission from the atrial contraction pressure waveform to velocity waves in the inferior vena cava, ductus venosus, intra- abdominal umbilical vein, and intra-amniotic umbilical vein were examined. Methods: Five lamb fetuses at 125-135 days' gestation were instrumented with solid state pressure transducers in the inferior vena cava, fluid-filled catheters in the inferior vena cava and descending aorta, and epicardial pacemakers. Three to 5 days postoperatively, inferior vena cava, ductus venosus, and umbilical vein velocities were examined with Doppler ultrasound. Normal saline was administered until umbilical vein velocity pulsations developed (180 ± 60 mL). In three fetuses, premature atrial contractions were induced under baseline conditions and after umbilical vein velocity pulsations developed. Results: Times of transmission from the atrial contraction pressure waveform until velocity decreases in the fetal venous system were significantly different in the inferior vena cava, ductus venosus, intra-abdominal umbilical vein, and intra-amniotic umbilical vein (P < .001). Times increased with the distance from the atrium. Inferior vena cava pressure increased with fluid administration from 3.7 ± 4.7 mmHg to 9.3 ± 2.3 mmHg (P < .01). Time from increased pressure waveforms with induced premature atrial contractions to the nadir of subsequent umbilical vein velocity waves decreased from 0.123 ± 0.047 seconds before saline administration to 0.072 ± 0.039 seconds after saline administration (P < .001). Conclusion: Transmission time of atrial pressure into the venous circulation increases with distance from the atrium and decreases with volume loading. Umbilical venous velocity pulsations derive from atrial pressure changes transmitted in a retrograde fashion.

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