Understanding allergic multimorbidity within the non-eosinophilic interactome

Daniel Aguilar, Nathanael Lemonnier, Gerard H. Koppelman, Erik Melén, Baldo Oliva, Mariona Pinart, Stefano Guerra, Jean Bousquet, Josep M. Anto

Research output: Contribution to journalArticle

Abstract

Background The mechanisms explaining multimorbidity between asthma, dermatitis and rhinitis (allergic multimorbidity) are not well known. We investigated these mechanisms and their specificity in distinct cell types by means of an interactome-based analysis of expression data. Methods Genes associated to the diseases were identified using data mining approaches, and their multimorbidity mechanisms in distinct cell types were characterized by means of an in silico analysis of the topology of the human interactome. Results We characterized specific pathomechanisms for multimorbidities between asthma, dermatitis and rhinitis for distinct emergent non-eosinophilic cell types. We observed differential roles for cytokine signaling, TLR-mediated signaling and metabolic pathways for multimorbidities across distinct cell types. Furthermore, we also identified individual genes potentially associated to multimorbidity mechanisms. Conclusions Our results support the existence of differentiated multimorbidity mechanisms between asthma, dermatitis and rhinitis at cell type level, as well as mechanisms common to distinct cell types. These results will help understanding the biology underlying allergic multimorbidity, assisting in the design of new clinical studies.

Original languageEnglish (US)
Article numbere0224448
JournalPloS one
Volume14
Issue number11
DOIs
StatePublished - Jan 1 2019

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Dermatitis
Comorbidity
rhinitis
asthma
dermatitis
Genes
cells
Data mining
Asthma
Rhinitis
Topology
Cytokines
topology
Data Mining
biochemical pathways
clinical trials
cytokines
genes
Metabolic Networks and Pathways
Computer Simulation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Aguilar, D., Lemonnier, N., Koppelman, G. H., Melén, E., Oliva, B., Pinart, M., ... Anto, J. M. (2019). Understanding allergic multimorbidity within the non-eosinophilic interactome. PloS one, 14(11), [e0224448]. https://doi.org/10.1371/journal.pone.0224448

Understanding allergic multimorbidity within the non-eosinophilic interactome. / Aguilar, Daniel; Lemonnier, Nathanael; Koppelman, Gerard H.; Melén, Erik; Oliva, Baldo; Pinart, Mariona; Guerra, Stefano; Bousquet, Jean; Anto, Josep M.

In: PloS one, Vol. 14, No. 11, e0224448, 01.01.2019.

Research output: Contribution to journalArticle

Aguilar, D, Lemonnier, N, Koppelman, GH, Melén, E, Oliva, B, Pinart, M, Guerra, S, Bousquet, J & Anto, JM 2019, 'Understanding allergic multimorbidity within the non-eosinophilic interactome', PloS one, vol. 14, no. 11, e0224448. https://doi.org/10.1371/journal.pone.0224448
Aguilar D, Lemonnier N, Koppelman GH, Melén E, Oliva B, Pinart M et al. Understanding allergic multimorbidity within the non-eosinophilic interactome. PloS one. 2019 Jan 1;14(11). e0224448. https://doi.org/10.1371/journal.pone.0224448
Aguilar, Daniel ; Lemonnier, Nathanael ; Koppelman, Gerard H. ; Melén, Erik ; Oliva, Baldo ; Pinart, Mariona ; Guerra, Stefano ; Bousquet, Jean ; Anto, Josep M. / Understanding allergic multimorbidity within the non-eosinophilic interactome. In: PloS one. 2019 ; Vol. 14, No. 11.
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