Understanding decision-making deficits in neurological conditions: Insights from models of natural action selection

Michael J. Frank, Anouk Scheres, Scott J Sherman

Research output: Contribution to journalArticle

113 Scopus citations


Models of natural action selection implicate fronto-striatal circuits in both motor and cognitive 'actions'. Dysfunction of these circuits leads to decision-making deficits in various populations. We review how computational models provide insights into the mechanistic basis for these deficits in Parkinson's patients and those with ventromedial frontal damage. We then consider implications of the models for understanding behaviour and cognition in attention-deficit/hyperactivity disorder (ADHD). Incorporation of cortical noradrenaline function into the model improves action selection in noisy environments and accounts for response variability in ADHD. We close with more general clinical implications.

Original languageEnglish (US)
Pages (from-to)1641-1654
Number of pages14
JournalPhilosophical transactions of the Royal Society of London. Series B: Biological sciences
Issue number1485
Publication statusPublished - Sep 29 2007



  • Action selection
  • Basal ganglia
  • Computational models
  • Decision making
  • Neurological disorders

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

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