Unexpected NRY chromosome variation in Northern Island Melanesia

Laura Scheinfeldt, Françoise Friedlaender, Jonathan Friedlaender, Krista Latham, George Koki, Tatiana Karafet, Michael F Hammer, Joseph Lorenz

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

To investigate the paternal population history of populations in Northern Island Melanesia, 685 paternally unrelated males from 36 populations in this region and New Guinea were analyzed at 14 regionally informative binary markers and 7 short tandem repeat (STR) loci from the nonrecombining portion of the Y chromosome. Three newly defined binary markers (K6-P79, K7-P117, and M2-P87) aided in identifying considerable heterozygosity that would have otherwise gone undetected. Judging from their geographic distributions and network analyses of their associated STR profiles, 4 lineages appear to have developed in this region and to be of considerable age: K6-P79, K7-P117, M2-P87, and M2a-P22. The origins of K5-M230 and M-M4 are also confirmed as being located further west, probably in New Guinea. In the 25 adequately sampled populations, the number of different haplogroups ranged from 2 in the single most isolated group (the Aita of Bougainville), to 9, and measures of molecular diversity were generally not particularly low. The resulting pattern contradicts earlier findings that suggested far lower male-mediated diversity and gene exchange rates in the region. However, these earlier studies had not included the newly defined haplogroups. We could only identify a very weak signal of recent male Southeast Asian genetic influence (<10%), which was almost entirely restricted to Austronesian (Oceanic)-speaking groups. This contradicts earlier assumptions on the ancestral composition of these groups and requires a revision of hypotheses concerning the settlement of the islands of the central Pacific, which commenced from this region.

Original languageEnglish (US)
Pages (from-to)1628-1641
Number of pages14
JournalMolecular Biology and Evolution
Volume23
Issue number8
DOIs
StatePublished - Aug 2006

Fingerprint

Melanesia
Chromosomes
Islands
Microsatellite Repeats
chromosome
New Guinea
chromosomes
Population
Genes
microsatellite repeats
Pacific Islands
Y Chromosome
Y chromosome
exchange rate
Chemical analysis
heterozygosity
geographical distribution
loci
gene
history

Keywords

  • Bismarck Archipelago
  • Melanesia
  • NRY
  • Pacific
  • Phylogeography

ASJC Scopus subject areas

  • Genetics
  • Biochemistry
  • Genetics(clinical)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Ecology, Evolution, Behavior and Systematics
  • Agricultural and Biological Sciences (miscellaneous)
  • Molecular Biology

Cite this

Scheinfeldt, L., Friedlaender, F., Friedlaender, J., Latham, K., Koki, G., Karafet, T., ... Lorenz, J. (2006). Unexpected NRY chromosome variation in Northern Island Melanesia. Molecular Biology and Evolution, 23(8), 1628-1641. https://doi.org/10.1093/molbev/msl028

Unexpected NRY chromosome variation in Northern Island Melanesia. / Scheinfeldt, Laura; Friedlaender, Françoise; Friedlaender, Jonathan; Latham, Krista; Koki, George; Karafet, Tatiana; Hammer, Michael F; Lorenz, Joseph.

In: Molecular Biology and Evolution, Vol. 23, No. 8, 08.2006, p. 1628-1641.

Research output: Contribution to journalArticle

Scheinfeldt, L, Friedlaender, F, Friedlaender, J, Latham, K, Koki, G, Karafet, T, Hammer, MF & Lorenz, J 2006, 'Unexpected NRY chromosome variation in Northern Island Melanesia', Molecular Biology and Evolution, vol. 23, no. 8, pp. 1628-1641. https://doi.org/10.1093/molbev/msl028
Scheinfeldt L, Friedlaender F, Friedlaender J, Latham K, Koki G, Karafet T et al. Unexpected NRY chromosome variation in Northern Island Melanesia. Molecular Biology and Evolution. 2006 Aug;23(8):1628-1641. https://doi.org/10.1093/molbev/msl028
Scheinfeldt, Laura ; Friedlaender, Françoise ; Friedlaender, Jonathan ; Latham, Krista ; Koki, George ; Karafet, Tatiana ; Hammer, Michael F ; Lorenz, Joseph. / Unexpected NRY chromosome variation in Northern Island Melanesia. In: Molecular Biology and Evolution. 2006 ; Vol. 23, No. 8. pp. 1628-1641.
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