Unifying evolutionary dynamics: From individual stochastic processes to macroscopic models

Nicolas Champagnat, Régis Ferrière, Sylvie Méléard

Research output: Contribution to journalArticlepeer-review

227 Scopus citations

Abstract

A distinctive signature of living systems is Darwinian evolution, that is, a propensity to generate as well as self-select individual diversity. To capture this essential feature of life while describing the dynamics of populations, mathematical models must be rooted in the microscopic, stochastic description of discrete individuals characterized by one or several adaptive traits and interacting with each other. The simplest models assume asexual reproduction and haploid genetics: an offspring usually inherits the trait values of her progenitor, except when a mutation causes the offspring to take a mutation step to new trait values; selection follows from ecological interactions among individuals. Here we present a rigorous construction of the microscopic population process that captures the probabilistic dynamics over continuous time of birth, mutation, and death, as influenced by the trait values of each individual, and interactions between individuals. A by-product of this formal construction is a general algorithm for efficient numerical simulation of the individual-level model. Once the microscopic process is in place, we derive different macroscopic models of adaptive evolution. These models differ in the renormalization they assume, i.e. in the limits taken, in specific orders, on population size, mutation rate, mutation step, while rescaling time accordingly. The macroscopic models also differ in their mathematical nature: deterministic, in the form of ordinary, integro-, or partial differential equations, or probabilistic, like stochastic partial differential equations or superprocesses. These models include extensions of Kimura's equation (and of its approximation for small mutation effects) to frequency- and density-dependent selection. A novel class of macroscopic models obtains when assuming that individual birth and death occur on a short timescale compared with the timescale of typical population growth. On a timescale of very rare mutations, we establish rigorously the models of "trait substitution sequences" and their approximation known as the "canonical equation of adaptive dynamics". We extend these models to account for mutation bias and random drift between multiple evolutionary attractors. The renormalization approach used in this study also opens promising avenues to study and predict patterns of life-history allometries, thereby bridging individual physiology, genetic variation, and ecological interactions in a common evolutionary framework.

Original languageEnglish (US)
Pages (from-to)297-321
Number of pages25
JournalTheoretical Population Biology
Volume69
Issue number3
DOIs
StatePublished - May 2006

Keywords

  • Adaptive dynamics
  • Adaptive evolution
  • Birth and death point process
  • Body size scaling
  • Canonical equation
  • Density-dependent selection
  • Frequency-dependent selection
  • Individual-based model
  • Invasion fitness
  • Large deviation principle
  • Mutagenesis
  • Nonlinear PDEs
  • Nonlinear stochastic partial differential equations
  • Timescale separation

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics

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