Abstract
This communication reveals a novel multicomponent oxidation of saturated, urethane protected nitrogen heterocyclic systems. The oxidation is facile, general, high yielding and involves the application of readily-made hypervalent iodine reagents, giving an α,β,β-oxidation pattern relative to the nitrogen of the heterocycle. The oxidation is multicomponent type III, in that the substrate, reagent and solvent provide the three inputs during the reaction. The transformation also represents an example of triple C-H bond activation. A mechanistic rationale for this is proposed.
Original language | English (US) |
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Pages (from-to) | 605-609 |
Number of pages | 5 |
Journal | Tetrahedron Letters |
Volume | 47 |
Issue number | 4 |
DOIs | |
State | Published - Jan 23 2006 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry