Unmasking the tonic-aversive state in neuropathic pain

Tamara King, Louis Vera-Portocarrero, Tannia Gutierrez, Todd W. Vanderah, Gregory Dussor, Josephine Lai, Howard L. Fields, Frank Porreca

Research output: Contribution to journalArticle

318 Scopus citations

Abstract

Tonic pain has been difficult to demonstrate in animals. Because relief of pain is rewarding, analgesic agents that are not rewarding in the absence of pain should become rewarding only when there is ongoing pain. We used conditioned place preference to concomitantly determine the presence of tonic pain in rats and the efficacy of agents that relieve it. This provides a new approach for investigating tonic pain in animals and for evaluating the analgesic effects of drugs.

Original languageEnglish (US)
Pages (from-to)1364-1366
Number of pages3
JournalNature neuroscience
Volume12
Issue number11
DOIs
StatePublished - Nov 1 2009

ASJC Scopus subject areas

  • Neuroscience(all)

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    King, T., Vera-Portocarrero, L., Gutierrez, T., Vanderah, T. W., Dussor, G., Lai, J., Fields, H. L., & Porreca, F. (2009). Unmasking the tonic-aversive state in neuropathic pain. Nature neuroscience, 12(11), 1364-1366. https://doi.org/10.1038/nn.2407