@inproceedings{87ad45ea2d5844c18a179b2a117a40fb,
title = "Unraveling gene regulatory networks using an integrated microfluidic platform",
abstract = "Systematic investigation of complex cellular systems using micro and nano devices has distinctive advantages over traditional approaches. The capabilities of performing time-varying stimulation and real-time monitoring of cells are invaluable for investigating dynamic biological systems, such as gene regulatory networks. In this work, we report a generic microfluidic platform, which is capable of long term cell cultivation, for investigating the complex dynamics of a transcription factor, nuclear factor kappa B (NF-κB). The temporal responses of NF-κB mediated gene expression were measured at the single cell level and the results were compared to a computational model. Our microfluidic platforms combining with advanced biotechnologies and computational techniques provide powerful tools for investigating complex biological networks.",
keywords = "Microlfuidics, Nuclear factor kappa B, Signaling pathways, Systems biology",
author = "Wong, {Pak Kin} and Fuqu Yu and Ren Sun and Ho, {Chin Ming}",
year = "2007",
month = dec,
day = "1",
doi = "10.1109/NANO.2007.4601192",
language = "English (US)",
isbn = "1424406080",
series = "2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings",
pages = "291--294",
booktitle = "2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings",
note = "2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007 ; Conference date: 02-08-2007 Through 05-08-2007",
}