Unraveling the pathophysiology of chronic stroke lesions could yield treatments for stroke-related dementia

Research output: Contribution to journalReview article

Abstract

Over the past few decades, there has been extensive research in both animal models and humans that has characterized the pathophysiology of stroke during the first few weeks. By contrast, however, there has been very little research into the chronic stage of infarction. This is an important area for future research because, as previously mentioned, more than 10 million individuals worldwide survive stroke each year and more than a third of these survivors subsequently develop dementia. The cause, or causes, of this dementia are unclear, and there are currently no neuroprotective drugs that can improve recovery and provide cognitive protection in the chronic time period. It is possible that there are still neurodegenerative processes that take place during the chronic stage of stroke recovery and this is a promising target for developing treatments for stroke-related dementia.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalFuture Neurology
Volume11
Issue number1
DOIs
StatePublished - Feb 1 2016

Fingerprint

Dementia
Stroke
Neuroprotective Agents
Research
Infarction
Animal Models

Keywords

  • chronic stroke
  • glial scars
  • inflammation
  • liquefactive necrosis
  • post-stroke dementia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Unraveling the pathophysiology of chronic stroke lesions could yield treatments for stroke-related dementia. / Doyle, Kristian.

In: Future Neurology, Vol. 11, No. 1, 01.02.2016, p. 1-4.

Research output: Contribution to journalReview article

@article{2219ad04959c4bfc8fa3c06809323892,
title = "Unraveling the pathophysiology of chronic stroke lesions could yield treatments for stroke-related dementia",
abstract = "Over the past few decades, there has been extensive research in both animal models and humans that has characterized the pathophysiology of stroke during the first few weeks. By contrast, however, there has been very little research into the chronic stage of infarction. This is an important area for future research because, as previously mentioned, more than 10 million individuals worldwide survive stroke each year and more than a third of these survivors subsequently develop dementia. The cause, or causes, of this dementia are unclear, and there are currently no neuroprotective drugs that can improve recovery and provide cognitive protection in the chronic time period. It is possible that there are still neurodegenerative processes that take place during the chronic stage of stroke recovery and this is a promising target for developing treatments for stroke-related dementia.",
keywords = "chronic stroke, glial scars, inflammation, liquefactive necrosis, post-stroke dementia",
author = "Kristian Doyle",
year = "2016",
month = "2",
day = "1",
doi = "10.2217/fnl.15.47",
language = "English (US)",
volume = "11",
pages = "1--4",
journal = "Future Neurology",
issn = "1479-6708",
publisher = "Future Medicine Ltd.",
number = "1",

}

TY - JOUR

T1 - Unraveling the pathophysiology of chronic stroke lesions could yield treatments for stroke-related dementia

AU - Doyle, Kristian

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Over the past few decades, there has been extensive research in both animal models and humans that has characterized the pathophysiology of stroke during the first few weeks. By contrast, however, there has been very little research into the chronic stage of infarction. This is an important area for future research because, as previously mentioned, more than 10 million individuals worldwide survive stroke each year and more than a third of these survivors subsequently develop dementia. The cause, or causes, of this dementia are unclear, and there are currently no neuroprotective drugs that can improve recovery and provide cognitive protection in the chronic time period. It is possible that there are still neurodegenerative processes that take place during the chronic stage of stroke recovery and this is a promising target for developing treatments for stroke-related dementia.

AB - Over the past few decades, there has been extensive research in both animal models and humans that has characterized the pathophysiology of stroke during the first few weeks. By contrast, however, there has been very little research into the chronic stage of infarction. This is an important area for future research because, as previously mentioned, more than 10 million individuals worldwide survive stroke each year and more than a third of these survivors subsequently develop dementia. The cause, or causes, of this dementia are unclear, and there are currently no neuroprotective drugs that can improve recovery and provide cognitive protection in the chronic time period. It is possible that there are still neurodegenerative processes that take place during the chronic stage of stroke recovery and this is a promising target for developing treatments for stroke-related dementia.

KW - chronic stroke

KW - glial scars

KW - inflammation

KW - liquefactive necrosis

KW - post-stroke dementia

UR - http://www.scopus.com/inward/record.url?scp=84975742298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975742298&partnerID=8YFLogxK

U2 - 10.2217/fnl.15.47

DO - 10.2217/fnl.15.47

M3 - Review article

VL - 11

SP - 1

EP - 4

JO - Future Neurology

JF - Future Neurology

SN - 1479-6708

IS - 1

ER -