Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience

Tom V. Adamkiewicz, Paul Szabolcs, Ann Haight, K. Scott Baker, Susan Staba, Amos Kedar, K. Y. Chiang, Lakshmanan Krishnamurti, Michael W. Boyer, Joan Kurtzberg, John E. Wagner, John R. Wingard, Andrew M. Yeager

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

UCBT was performed in seven children with SCD and stroke (HLA match 4/6 n = 5; 5/6 n = 2). Four received myeloablative regimens (BU, CY, ATG plus FLU in one patient). One had primary graft failure, three had sustained engraftment, two with grade III-IV GVHD (one died, one developed chronic GVHD), one with stable mixed chimerism. Three patients treated with reduced-intensity regimens (FLU, BU or CY, ATG, TLI) failed to engraft; one engrafted after second UCBT (HU, TT, RXA, ALZ, TBI). Four patients (57%) developed viral infections. Engraftment, GVHD, and infection remain challenges.

Original languageEnglish (US)
Pages (from-to)641-644
Number of pages4
JournalPediatric transplantation
Volume11
Issue number6
DOIs
StatePublished - Sep 1 2007

Keywords

  • Reduced intensity conditioning
  • Sickle cell disease
  • Umbilical cord transplant
  • Unrelated donor transplant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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    Adamkiewicz, T. V., Szabolcs, P., Haight, A., Baker, K. S., Staba, S., Kedar, A., Chiang, K. Y., Krishnamurti, L., Boyer, M. W., Kurtzberg, J., Wagner, J. E., Wingard, J. R., & Yeager, A. M. (2007). Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience. Pediatric transplantation, 11(6), 641-644. https://doi.org/10.1111/j.1399-3046.2007.00725.x