Unrelated donor bone marrow transplantation for children and adolescents with aplastic anaemia or myelodysplasia

Stella M. Davies, John E. Wagner, Todd Defor, Bruce R. Blazar, Emmanuel Katsanis, John H. Kersey, Paul J. Orchard, Phillip B. Mcglave, Daniel J. Weisdorf, Norma K C Ramsay

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Allogeneic transplantation from an HLA-matched family member has been shown to be effective in reconstituting normal haemopoiesis in young people with severe cytopenias, classified as myelodysplastic syndrome (MDS) or severe aplastic anaemia (SAA). Unrelated donor transplant is a therapeutic choice for patients without a suitable family member donor. We report the outcome of seven patients < 20 years old with SAA and 10 with MDS treated with BMT from an HLA A,B DRB1 matched (n = 8) or A or B locus mismatched (n = 9) unrelated donor at the University of Minnesota between March 1988 and August 1995. Primary graft failure occurred in two patients and secondary graft failure in one, who was subsequently successfully engrafted with a second donor marrow infusion. Grades II-IV GVHD occurred in 10/16 (63%), and grades III-IV in 6/16 (37%) evaluable patients. Nine of the 17 patients (six with MDS and three with SAA) survive with full donor chimaerism, a median of 1.2 years post-BMT (range 3 months to 7 years). We recommend early referral for consideration of unrelated donor BMT for young patients with MDS, and patients with SAA without response to immunosuppression.

Original languageEnglish (US)
Pages (from-to)749-756
Number of pages8
JournalBritish Journal of Haematology
Volume96
Issue number4
StatePublished - 1997
Externally publishedYes

Fingerprint

Unrelated Donors
Aplastic Anemia
Bone Marrow Transplantation
Myelodysplastic Syndromes
Tissue Donors
Transplants
HLA-A Antigens
HLA-B Antigens
Homologous Transplantation
Immunosuppression
Referral and Consultation
Bone Marrow

Keywords

  • aplastic anaemia
  • bone marrow transplant
  • myelodysplastic syndrome
  • unrelated donor

ASJC Scopus subject areas

  • Hematology

Cite this

Davies, S. M., Wagner, J. E., Defor, T., Blazar, B. R., Katsanis, E., Kersey, J. H., ... Ramsay, N. K. C. (1997). Unrelated donor bone marrow transplantation for children and adolescents with aplastic anaemia or myelodysplasia. British Journal of Haematology, 96(4), 749-756.

Unrelated donor bone marrow transplantation for children and adolescents with aplastic anaemia or myelodysplasia. / Davies, Stella M.; Wagner, John E.; Defor, Todd; Blazar, Bruce R.; Katsanis, Emmanuel; Kersey, John H.; Orchard, Paul J.; Mcglave, Phillip B.; Weisdorf, Daniel J.; Ramsay, Norma K C.

In: British Journal of Haematology, Vol. 96, No. 4, 1997, p. 749-756.

Research output: Contribution to journalArticle

Davies, SM, Wagner, JE, Defor, T, Blazar, BR, Katsanis, E, Kersey, JH, Orchard, PJ, Mcglave, PB, Weisdorf, DJ & Ramsay, NKC 1997, 'Unrelated donor bone marrow transplantation for children and adolescents with aplastic anaemia or myelodysplasia', British Journal of Haematology, vol. 96, no. 4, pp. 749-756.
Davies, Stella M. ; Wagner, John E. ; Defor, Todd ; Blazar, Bruce R. ; Katsanis, Emmanuel ; Kersey, John H. ; Orchard, Paul J. ; Mcglave, Phillip B. ; Weisdorf, Daniel J. ; Ramsay, Norma K C. / Unrelated donor bone marrow transplantation for children and adolescents with aplastic anaemia or myelodysplasia. In: British Journal of Haematology. 1997 ; Vol. 96, No. 4. pp. 749-756.
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