TY - JOUR
T1 - Urinary excretion of modified nucleosides as biological marker of RNA turnover in patients with cancer and AIDS
AU - Nakano, Katsuyuki
AU - Nakao, Terutoshi
AU - Schram, Karl H.
AU - Hammargren, William M.
AU - McClure, Thomas D.
AU - Katz, Michael
AU - Petersen, Esklid
PY - 1993/9/30
Y1 - 1993/9/30
N2 - Using boronate gel affinity chromatography and reversed-phase high-performance liquid chromatography (RP-HPLC), a method for the simultaneous determination of 12 urinary modified nucleosides has been developed. The RP-HPLC fractions were identified by gas chromatography/mass spectrometry analysis. The HPLC quantitation of urinary nucleoside levels before and after surgery of cancer patients suggested that urinary 5′-deoxy-5′-.
AB - Using boronate gel affinity chromatography and reversed-phase high-performance liquid chromatography (RP-HPLC), a method for the simultaneous determination of 12 urinary modified nucleosides has been developed. The RP-HPLC fractions were identified by gas chromatography/mass spectrometry analysis. The HPLC quantitation of urinary nucleoside levels before and after surgery of cancer patients suggested that urinary 5′-deoxy-5′-.
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U2 - 10.1016/0009-8981(93)90181-3
DO - 10.1016/0009-8981(93)90181-3
M3 - Article
C2 - 7508341
AN - SCOPUS:0027329792
VL - 218
SP - 169
EP - 183
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
IS - 2
ER -