Urinary polyamine levels are markers of altered T lymphocyte proliferation/loss and rejection in heart transplant patients

J. R. Womble, D. F. Larson, J. G. Copeland, D. H. Russell

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The studies of urinary polyamine excretion in heart transplant patients reported in this article indicate that total urinary polyamine excretion is increased one to three days before a biopsy-proved rejection in conventionally treated patients, the acetylputrescine to N1-acetylspermidine ratio becomes elevated before rejection in cyclosporine-treated patients, and the response to elevated ATG therapy during rejection can be evaluated by monitoring urinary polyamine concentrations. We conclude that daily monitoring of urinary polyamine levels may provide a noninvasive biochemical marker that precedes rejection and which parallels the extent of T lymphocyte suppression during the course of immunosuppressive drug therapy.

Original languageEnglish (US)
Pages (from-to)1573-1575
Number of pages3
JournalTransplantation Proceedings
Volume16
Issue number6
StatePublished - Dec 1 1984

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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