Abstract
The studies of urinary polyamine excretion in heart transplant patients reported in this article indicate that total urinary polyamine excretion is increased one to three days before a biopsy-proved rejection in conventionally treated patients, the acetylputrescine to N1-acetylspermidine ratio becomes elevated before rejection in cyclosporine-treated patients, and the response to elevated ATG therapy during rejection can be evaluated by monitoring urinary polyamine concentrations. We conclude that daily monitoring of urinary polyamine levels may provide a noninvasive biochemical marker that precedes rejection and which parallels the extent of T lymphocyte suppression during the course of immunosuppressive drug therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1573-1575 |
| Number of pages | 3 |
| Journal | Transplantation Proceedings |
| Volume | 16 |
| Issue number | 6 |
| State | Published - 1984 |
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ASJC Scopus subject areas
- Surgery
- Transplantation
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Urinary polyamine levels are markers of altered T lymphocyte proliferation/loss and rejection in heart transplant patients. / Womble, J. R.; Larson, Douglas F; Copeland, J. G.; Russell, D. H.
In: Transplantation Proceedings, Vol. 16, No. 6, 1984, p. 1573-1575.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Urinary polyamine levels are markers of altered T lymphocyte proliferation/loss and rejection in heart transplant patients
AU - Womble, J. R.
AU - Larson, Douglas F
AU - Copeland, J. G.
AU - Russell, D. H.
PY - 1984
Y1 - 1984
N2 - The studies of urinary polyamine excretion in heart transplant patients reported in this article indicate that total urinary polyamine excretion is increased one to three days before a biopsy-proved rejection in conventionally treated patients, the acetylputrescine to N1-acetylspermidine ratio becomes elevated before rejection in cyclosporine-treated patients, and the response to elevated ATG therapy during rejection can be evaluated by monitoring urinary polyamine concentrations. We conclude that daily monitoring of urinary polyamine levels may provide a noninvasive biochemical marker that precedes rejection and which parallels the extent of T lymphocyte suppression during the course of immunosuppressive drug therapy.
AB - The studies of urinary polyamine excretion in heart transplant patients reported in this article indicate that total urinary polyamine excretion is increased one to three days before a biopsy-proved rejection in conventionally treated patients, the acetylputrescine to N1-acetylspermidine ratio becomes elevated before rejection in cyclosporine-treated patients, and the response to elevated ATG therapy during rejection can be evaluated by monitoring urinary polyamine concentrations. We conclude that daily monitoring of urinary polyamine levels may provide a noninvasive biochemical marker that precedes rejection and which parallels the extent of T lymphocyte suppression during the course of immunosuppressive drug therapy.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021709458&partnerID=8YFLogxK
M3 - Article
C2 - 6390864
AN - SCOPUS:0021709458
VL - 16
SP - 1573
EP - 1575
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 6
ER -