Abstract
The studies of urinary polyamine excretion in heart transplant patients reported in this article indicate that total urinary polyamine excretion is increased one to three days before a biopsy-proved rejection in conventionally treated patients, the acetylputrescine to N1-acetylspermidine ratio becomes elevated before rejection in cyclosporine-treated patients, and the response to elevated ATG therapy during rejection can be evaluated by monitoring urinary polyamine concentrations. We conclude that daily monitoring of urinary polyamine levels may provide a noninvasive biochemical marker that precedes rejection and which parallels the extent of T lymphocyte suppression during the course of immunosuppressive drug therapy.
Original language | English (US) |
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Pages (from-to) | 1573-1575 |
Number of pages | 3 |
Journal | Transplantation Proceedings |
Volume | 16 |
Issue number | 6 |
State | Published - Dec 1 1984 |
ASJC Scopus subject areas
- Surgery
- Transplantation