9-Methylfluorene was tested as an indicator in the titration of commonly used organometallic reagents. This indicator is readily prepared in three steps from fluorenone. In THF solution the deprotonated indicator is red and exhibits a sharp endpoint. The highly basic reagents secbutyllithium and tert-butyllithium can be titrated in ether solution, where the color of the deprotonated indicator is yellow.
ASJC Scopus subject areas
- Organic Chemistry