Use of a novel array detector for the direct analysis of solid samples by laser ablation inductively coupled plasma sector-field mass spectrometry

James H. Barnes IV, Gregory D. Schilling, Gary M. Hieftje, Roger P. Sperline, M. Bonner Denton, Charles J. Barinaga, David W. Koppenaal

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The use of laser ablation (LA) as a sample-introduction method for inductively coupled plasma mass spectrometry (ICP-MS) creates a powerful tool for trace elemental analysis. With this type of instrument, high analyte spatial resolution is possible in three dimensions with ng/g limits of detection and minimal sample consumption. Here, simultaneous detection is used to eliminate the correlated noise that plagues the ablation process. This benefit allows analyses to be performed with single laser pulses, resulting in improved depth resolution, even less sample consumption, and improved measurement precision. The new instrument includes an LA sample-introduction system coupled to an ICP ionization source and a Mattauch-Herzog mass spectrograph (MHMS) fitted with a novel array detector. With this instrument, absolute limits of detection are in the tens to hundreds of fg regime and isotope-ratio precision is better than 0.02% RSD with a one-hour integration period. Finally, depth-profile analysis has been performed with a depth resolution of 5 nm per ablation event.

Original languageEnglish (US)
Pages (from-to)769-776
Number of pages8
JournalJournal of the American Society for Mass Spectrometry
Volume15
Issue number6
DOIs
StatePublished - Jun 1 2004

ASJC Scopus subject areas

  • Structural Biology
  • Spectroscopy

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