Use of automated solid-phase extraction and GC-MS/MS to evaluate nitrosamines in water matrices

Janie C. Holady, Rebecca A. Trenholm, Shane A Snyder

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

An analytical method for detecting nitrosamines was demonstrated in various water matrices, finished drinking, surface, and treated wastewater effluent. The method uses automated solid-phase extraction (ASPE) followed by analysis with GC-MS/MS using positive chemical ionization (PCI), quantitation was performed using isotope dilution. N-nitrosodimethylamine (NDMA) occurrence was evaluated in effluent from an Australian facility over a three-month period and ranged from 11 to 14 ng/L. Automated flow rates and solvent switching systems are more consistent than manual systems. The automated programming provides a batch run time of 1 hr, 45 min. ASPE achieves a high degree of sample throughput and maintains reproducibility. The technique demonstrates improved sample throughput over traditional methods of extraction.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalAmerican Laboratory
Volume44
Issue number3
StatePublished - Mar 2012

Fingerprint

Nitrosamines
Solid Phase Extraction
Water
Effluents
Throughput
Dimethylnitrosamine
Switching systems
Waste Water
Isotopes
Dilution
Drinking
Ionization
Wastewater
Flow rate

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Use of automated solid-phase extraction and GC-MS/MS to evaluate nitrosamines in water matrices. / Holady, Janie C.; Trenholm, Rebecca A.; Snyder, Shane A.

In: American Laboratory, Vol. 44, No. 3, 03.2012, p. 25-30.

Research output: Contribution to journalArticle

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