Use of automated solid-phase extraction and GC-MS/MS to evaluate nitrosamines in water matrices

Janie C. Holady, Rebecca A. Trenholm, Shane A. Snyder

Research output: Contribution to specialist publicationArticle

18 Scopus citations


An analytical method for detecting nitrosamines was demonstrated in various water matrices, finished drinking, surface, and treated wastewater effluent. The method uses automated solid-phase extraction (ASPE) followed by analysis with GC-MS/MS using positive chemical ionization (PCI), quantitation was performed using isotope dilution. N-nitrosodimethylamine (NDMA) occurrence was evaluated in effluent from an Australian facility over a three-month period and ranged from 11 to 14 ng/L. Automated flow rates and solvent switching systems are more consistent than manual systems. The automated programming provides a batch run time of 1 hr, 45 min. ASPE achieves a high degree of sample throughput and maintains reproducibility. The technique demonstrates improved sample throughput over traditional methods of extraction.

Original languageEnglish (US)
Number of pages6
Specialist publicationAmerican Laboratory
StatePublished - Mar 1 2012


ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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