Use of halothane as a model for investigating chemical-induced autoimmune hepatotoxicity

Sylvia M. Furst, Mingli Chen, A Jay Gandolfi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Adverse drug reactions are usually unpredictable. The mechanisms by which these reactions occur are poorly understood but often involve the immune system. The volatile anesthetic halothane has evolved as a model drug for investigating chemical-induced autoimmune hepatotoxicity. It has been shown that during the biotransformation of halothane, adducts are formed with liver proteins which can be recognized as neoantigens. These adducts have been associated with the production of a humoral and cellular immune response in a guinea pig model of halothane hepatotoxicity. This model has been used to examine the various aspects of an autoimmune response and the authors' attempts to correlate the immune response to the liver injury.

Original languageEnglish (US)
Pages (from-to)301-307
Number of pages7
JournalDrug Information Journal
Volume30
Issue number1
StatePublished - 1996

Fingerprint

Chemical Models
Halothane
Liver
Immune system
Humoral Immunity
Biotransformation
Drug-Related Side Effects and Adverse Reactions
Autoimmunity
Cellular Immunity
Pharmaceutical Preparations
Anesthetics
Immune System
Guinea Pigs
Wounds and Injuries
Proteins

Keywords

  • Anesthetics
  • Autoimmunity
  • Hepatotoxicity
  • Hypersensitivity
  • Idiosyncractic

ASJC Scopus subject areas

  • Health Informatics
  • Public Health, Environmental and Occupational Health
  • Pharmacology
  • Nursing(all)

Cite this

Use of halothane as a model for investigating chemical-induced autoimmune hepatotoxicity. / Furst, Sylvia M.; Chen, Mingli; Gandolfi, A Jay.

In: Drug Information Journal, Vol. 30, No. 1, 1996, p. 301-307.

Research output: Contribution to journalArticle

@article{8927e1a256bf4099b301291a095a4aaf,
title = "Use of halothane as a model for investigating chemical-induced autoimmune hepatotoxicity",
abstract = "Adverse drug reactions are usually unpredictable. The mechanisms by which these reactions occur are poorly understood but often involve the immune system. The volatile anesthetic halothane has evolved as a model drug for investigating chemical-induced autoimmune hepatotoxicity. It has been shown that during the biotransformation of halothane, adducts are formed with liver proteins which can be recognized as neoantigens. These adducts have been associated with the production of a humoral and cellular immune response in a guinea pig model of halothane hepatotoxicity. This model has been used to examine the various aspects of an autoimmune response and the authors' attempts to correlate the immune response to the liver injury.",
keywords = "Anesthetics, Autoimmunity, Hepatotoxicity, Hypersensitivity, Idiosyncractic",
author = "Furst, {Sylvia M.} and Mingli Chen and Gandolfi, {A Jay}",
year = "1996",
language = "English (US)",
volume = "30",
pages = "301--307",
journal = "Drug Information Journal",
issn = "0092-8615",
publisher = "Drug Information Association",
number = "1",

}

TY - JOUR

T1 - Use of halothane as a model for investigating chemical-induced autoimmune hepatotoxicity

AU - Furst, Sylvia M.

AU - Chen, Mingli

AU - Gandolfi, A Jay

PY - 1996

Y1 - 1996

N2 - Adverse drug reactions are usually unpredictable. The mechanisms by which these reactions occur are poorly understood but often involve the immune system. The volatile anesthetic halothane has evolved as a model drug for investigating chemical-induced autoimmune hepatotoxicity. It has been shown that during the biotransformation of halothane, adducts are formed with liver proteins which can be recognized as neoantigens. These adducts have been associated with the production of a humoral and cellular immune response in a guinea pig model of halothane hepatotoxicity. This model has been used to examine the various aspects of an autoimmune response and the authors' attempts to correlate the immune response to the liver injury.

AB - Adverse drug reactions are usually unpredictable. The mechanisms by which these reactions occur are poorly understood but often involve the immune system. The volatile anesthetic halothane has evolved as a model drug for investigating chemical-induced autoimmune hepatotoxicity. It has been shown that during the biotransformation of halothane, adducts are formed with liver proteins which can be recognized as neoantigens. These adducts have been associated with the production of a humoral and cellular immune response in a guinea pig model of halothane hepatotoxicity. This model has been used to examine the various aspects of an autoimmune response and the authors' attempts to correlate the immune response to the liver injury.

KW - Anesthetics

KW - Autoimmunity

KW - Hepatotoxicity

KW - Hypersensitivity

KW - Idiosyncractic

UR - http://www.scopus.com/inward/record.url?scp=0030021585&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030021585&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0030021585

VL - 30

SP - 301

EP - 307

JO - Drug Information Journal

JF - Drug Information Journal

SN - 0092-8615

IS - 1

ER -