Use of halothane as a model for investigating chemical-induced autoimmune hepatotoxicity

Sylvia M. Furst, Mingli Chen, A Jay Gandolfi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Adverse drug reactions are usually unpredictable. The mechanisms by which these reactions occur are poorly understood but often involve the immune system. The volatile anesthetic halothane has evolved as a model drug for investigating chemical-induced autoimmune hepatotoxicity. It has been shown that during the biotransformation of halothane, adducts are formed with liver proteins which can be recognized as neoantigens. These adducts have been associated with the production of a humoral and cellular immune response in a guinea pig model of halothane hepatotoxicity. This model has been used to examine the various aspects of an autoimmune response and the authors' attempts to correlate the immune response to the liver injury.

Original languageEnglish (US)
Pages (from-to)301-307
Number of pages7
JournalTherapeutic Innovation & Regulatory Science
Volume30
Issue number1
DOIs
StatePublished - 1996

Fingerprint

Chemical Models
Halothane
Liver
Humoral Immunity
Biotransformation
Drug-Related Side Effects and Adverse Reactions
Autoimmunity
Cellular Immunity
Anesthetics
Immune System
Guinea Pigs
Wounds and Injuries
Pharmaceutical Preparations
Proteins

Keywords

  • Anesthetics
  • Autoimmunity
  • Hepatotoxicity
  • Hypersensitivity
  • Idiosyncractic

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)

Cite this

Use of halothane as a model for investigating chemical-induced autoimmune hepatotoxicity. / Furst, Sylvia M.; Chen, Mingli; Gandolfi, A Jay.

In: Therapeutic Innovation & Regulatory Science, Vol. 30, No. 1, 1996, p. 301-307.

Research output: Contribution to journalArticle

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