Use of salmeterol with and without concurrent use of inhaled corticosteroids and the risk of asthma-related hospitalization among patients with asthma

Meng Ting Wang, Grant H. Skrepnek, Edward Armstrong, Duane L. Sherrill, Robin B. Harris, Cheng Liang Tsai, Daniel C. Malone

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Rationale: Studies evaluating the safety of salmeterol are inconclusive, which might be the result from not taking into account the impact of concomitant inhaled corticosteroids (ICS). Objective: To study whether salmeterol use with and without concomitant ICS, respectively, was associated with an increased risk of asthma-related hospitalizations among patients with asthma. Methods: A case-control study nested within a cohort of patients with asthma, identified in the year 2000, over a 2-year period was conducted. Cases were subjects who had a first-time hospitalization for asthma in the year 2001, and were matched with up to five controls by age (± 5 years), sex, and number of asthma-related outpatient visits. Measurements: Hospitalizations and medication use were extracted from the MEDSTAT's MarketScan database. Main results: There were 333 cases of asthma-related hospitalizations and 1607 matched control subjects. Any use of salmeterol with concomitant ICS use during the prior year was associated with a 32% risk reduction for being hospitalized due to asthma (OR = 0.68; 95% CI = 0.48, 0.96). In the presence of concomitant ICS use, patients who either used salmeterol currently or used seven or more canisters of salmeterol during the prior year had 46% (OR = 0.54, 95% CI = 0.32, 0.92), and 59% (OR = 0.41, 95% CI = 0.21, 0.79) reductions in the risk of hospital admissions for asthma, respectively. Limitations: Though indirect measure of asthma severity was adjusted during the analyses, the lack of information on lung function might result in a selection bias. Additionally, only a small sample size of patients was found to use salmeterol without concomitant ICS use, and this introduced the issue of lack of power. Conclusions: Use of salmeterol in conjunction with ICS is associated with a decreased risk of hospital admission for asthma.

Original languageEnglish (US)
Pages (from-to)859-867
Number of pages9
JournalCurrent Medical Research and Opinion
Volume24
Issue number3
DOIs
StatePublished - Mar 1 2008

Keywords

  • Asthma
  • Drug safety
  • Hospitalization
  • Inhaled corticosteroids
  • Long-acting beta-agonists
  • Salmeterol

ASJC Scopus subject areas

  • Medicine(all)

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