Use of tissue slices in chemical mixture toxicology and interspecies investigations

A. Jay Gandolfi, Klaus Brendel, Robyn L. Fisher, John Pierre Michaud

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Precision-cut tissue slices have proven to be a useful in vitro system for biotransformation and toxicity studies. Since tissue slices can be readily prepared from a variety of tissues and species, they can easily be used for interspecies investigations and comparisons. Furthermore, slices can be readily prepared from human tissue, thus comparisons (extrapolation) can be made between laboratory animals and humans. Slices can also be used to examine the toxic interactions of chemicals in vitro. It is important to use the correct experimental design to demonstrate toxic interactions and to assure that the tissue slices are properly exposed to the chemicals. Overall, tissue slices offer a valid in vitro system for performing species comparisons and chemical-chemical interaction studies.

Original languageEnglish (US)
Pages (from-to)285-290
Number of pages6
JournalToxicology
Volume105
Issue number2-3
DOIs
StatePublished - Dec 28 1995

Keywords

  • Interactions
  • Interspecies
  • Mixtures
  • Tissue slices

ASJC Scopus subject areas

  • Toxicology

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