Using bacteria to express and display anti-parasite molecules in mosquitoes: Current and future strategies

Michael A. Riehle, Marcelo Jacobs-Lorena

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Vector-borne diseases impose enormous health and economical burdens throughout the world. Unfortunately, as insecticide and drug resistance spread, these burdens will increase unless new control measures are developed. Genetically modifying vectors to be incapable of transmitting parasites is one possible control strategy and much progress has been made towards this goal. Numerous effector molecules have been identified that interfere with parasite development in its insect vectors, and techniques for transforming the vectors with genes encoding these molecules have been established. While the ability to generate refractory vectors is close at hand, a mechanism for replacing a wild vector population with a refractory one remains elusive. This review examines the feasibility of using bacteria to deliver the anti-parasitic effector molecules to wild vector populations. The first half briefly examines paratransgenic approaches currently being tested in both the triatomine bug and tsetse fly. The second half explores the possibility of using midgut bacteria to control malaria transmission by Anopheles mosquitoes.

Original languageEnglish (US)
Pages (from-to)699-707
Number of pages9
JournalInsect Biochemistry and Molecular Biology
Volume35
Issue number7
DOIs
StatePublished - Jul 1 2005
Externally publishedYes

Keywords

  • Bacteria
  • Malaria
  • Mosquito
  • Paratransgenic
  • Plasmodium

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Insect Science

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