Using optical coherence tomography to evaluate glaucoma implant healing response in rabbit eyes

Kirk W. Gossage, Tomasz S. Tkaczyk, Jennifer K. Barton

Research output: Contribution to journalConference article

Abstract

Glaucoma is a set of diseases that cause optic nerve damage and visual field loss. The most important risk factor for the development of glaucoma is elevated intraocular pressure. One approach used to alleviate the pressure increase is to surgically install glaucoma implants. Two standard Ahmed and ten experimental ePTFE implants were evaluated in this study in rabbit eyes. The implants were imaged with optical coherence tomography (OCT) at 0, 7, 15, 30, and 90 days after implantation. Histology was collected at days 7, 15, 30, and 90 and compared to the OCT images. Preliminary analysis of images indicates that OCT can visualize the development of fibrous encapsulation of the implant, tissue erosion, fibrin accumulation in the implant tube, and tube position in the anterior chamber. A new OCT handheld probe was developed to facilitate in vivo imaging in rabbit eye studies. The OCT probe consists of a mechanical scaffold designed to allow the imaging fiber to be held in a fixed position with respect to the rabbit eye, with minimal anesthesia. A piezo electric lateral scanning device allows the imaging fiber to be scanned across the tissue so that 2-D images may be acquired.

Original languageEnglish (US)
Pages (from-to)37-47
Number of pages11
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4611
DOIs
StatePublished - Jan 1 2002
EventOphthalmic Technologies XII - San Jose, CA, United States
Duration: Jan 19 2002Jan 20 2002

Keywords

  • Ahmed
  • ePTFE
  • Tissue healing

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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