Using optical coherence tomography to evaluate skin sun damage and precancer

Vrushali R. Korde, Garret T. Bonnema, Wei Xu, Chetankumar Krishnamurthy, James Ranger-Moore, Kathylynn Saboda, Lisa D. Slayton, Stuart J. Salasche, James A Warneke, David S Alberts, Jennifer K Barton

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Background and Objectives: Optical coherence tomography (OCT) is a depth resolved imaging modality that may aid in identifying sun damaged skin and the precancerous condition actinic keratosis (AK). Study Design/Materials and Methods: OCT images were acquired of 112 patients at 2 sun protected and 2 sun exposed sites, with a subsequent biopsy. Each site received a dermatological evaluation, a histological diagnosis, and a solar elastosis (SE) score. OCT images were examined visually and statistically analyzed. Results: Characteristic OCT image features were identified of sun protected, undiseased, sun damaged, and AK skin. A statistically significant difference (P < 0.0001) between the average attenuation values of skin with minimal and severe solar elastosis was observed. Significant differences (P < 0.0001) were also found between undiseased skin and AK using a gradient analysis. Using image features, AK could be distinguished from undiseased skin with 86% sensitivity and 83% specificity. Conclusion: OCT has the potential to guide biopsies and provide non-invasive measures of skin sun damage and disease state, possibly increasing efficiency of chemopreventive agent trials.

Original languageEnglish (US)
Pages (from-to)687-695
Number of pages9
JournalLasers in Surgery and Medicine
Volume39
Issue number9
DOIs
StatePublished - Oct 2007

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Optical Coherence Tomography
Solar System
Actinic Keratosis
Skin
Precancerous Conditions
Biopsy
Sensitivity and Specificity

Keywords

  • Actinic keratosis
  • Image processing
  • Imaging
  • Skin cancer

ASJC Scopus subject areas

  • Surgery

Cite this

Korde, V. R., Bonnema, G. T., Xu, W., Krishnamurthy, C., Ranger-Moore, J., Saboda, K., ... Barton, J. K. (2007). Using optical coherence tomography to evaluate skin sun damage and precancer. Lasers in Surgery and Medicine, 39(9), 687-695. https://doi.org/10.1002/lsm.20573

Using optical coherence tomography to evaluate skin sun damage and precancer. / Korde, Vrushali R.; Bonnema, Garret T.; Xu, Wei; Krishnamurthy, Chetankumar; Ranger-Moore, James; Saboda, Kathylynn; Slayton, Lisa D.; Salasche, Stuart J.; Warneke, James A; Alberts, David S; Barton, Jennifer K.

In: Lasers in Surgery and Medicine, Vol. 39, No. 9, 10.2007, p. 687-695.

Research output: Contribution to journalArticle

Korde, VR, Bonnema, GT, Xu, W, Krishnamurthy, C, Ranger-Moore, J, Saboda, K, Slayton, LD, Salasche, SJ, Warneke, JA, Alberts, DS & Barton, JK 2007, 'Using optical coherence tomography to evaluate skin sun damage and precancer', Lasers in Surgery and Medicine, vol. 39, no. 9, pp. 687-695. https://doi.org/10.1002/lsm.20573
Korde VR, Bonnema GT, Xu W, Krishnamurthy C, Ranger-Moore J, Saboda K et al. Using optical coherence tomography to evaluate skin sun damage and precancer. Lasers in Surgery and Medicine. 2007 Oct;39(9):687-695. https://doi.org/10.1002/lsm.20573
Korde, Vrushali R. ; Bonnema, Garret T. ; Xu, Wei ; Krishnamurthy, Chetankumar ; Ranger-Moore, James ; Saboda, Kathylynn ; Slayton, Lisa D. ; Salasche, Stuart J. ; Warneke, James A ; Alberts, David S ; Barton, Jennifer K. / Using optical coherence tomography to evaluate skin sun damage and precancer. In: Lasers in Surgery and Medicine. 2007 ; Vol. 39, No. 9. pp. 687-695.
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