Using thyroid hormone in brain-dead donors to maximize the number of organs available for transplantation

Ali Salim, Matthew Martin, Carlos Brown, Kenji Inaba, Bradley Roth, Pantelis Hadjizacharia, Angela Mascarenhas, Peter Rhee, Demetrios Demetriades

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

The aggressive management of brain-dead (cadaveric) organ donors has been shown to increase organs available for transplantation. Some centers use hormone therapy with thyroid hormone (T4) in selected donors. The purpose of this study is to evaluate the effects of T4 on organs available for transplantation. A policy of aggressive donor management was adopted at our trauma center in 1998. T4 therapy is reserved for the hemodynamically unstable donors who require significant vasopressor support. The records of patients who successfully donated organs between January 2001 and December 2005 were reviewed. Organ donor demographics and whether T4 was used was examined for each donor. T4 was used in 96 of 123 donors (78%). Compared with donors who did not receive T4, those that did were similar in age (32 ± 14 vs. 38 ± 21, p = 0.148), had more organs donated (3.9 ± 1.7 vs. 3.2 ± 1.7, p = 0.048), and had no differences in brain-death related complications. Despite the severe hemodynamic instability in the T4 group, the number of organs harvested from this group was significantly more than in patients who did not receive T4. The use of T4 in this group may result in the increased salvage of transplantable organs.

Original languageEnglish (US)
Pages (from-to)405-409
Number of pages5
JournalClinical Transplantation
Volume21
Issue number3
DOIs
StatePublished - May 1 2007

Keywords

  • Brain death
  • Organdonor
  • Thyroid hormone
  • Transplantation

ASJC Scopus subject areas

  • Transplantation

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    Salim, A., Martin, M., Brown, C., Inaba, K., Roth, B., Hadjizacharia, P., Mascarenhas, A., Rhee, P., & Demetriades, D. (2007). Using thyroid hormone in brain-dead donors to maximize the number of organs available for transplantation. Clinical Transplantation, 21(3), 405-409. https://doi.org/10.1111/j.1399-0012.2007.00659.x