Uterine microbiota: Residents, tourists, or invaders?

James M. Baker, Dana M. Chase, Melissa Herbst-Kralovetz

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Uterine microbiota have been reported under various conditions and populations; however, it is uncertain the level to which these bacteria are residents that maintain homeostasis, tourists that are readily eliminated or invaders that contribute to human disease. This review provides a historical timeline and summarizes the current status of this topic with the aim of promoting research priorities and discussion on this controversial topic. Discrepancies exist in current reports of uterine microbiota and are critically reviewed and examined. Established and putative routes of bacterial seeding of the human uterus and interactions with distal mucosal sites are discussed. Based upon the current literature, we highlight the need for additional robust clinical and translational studies in this area. In addition, we discuss the necessity for investigating host-microbiota interactions and the physiologic and functional impact of these microbiota on the local endometrial microenvironment as these mechanisms may influence poor reproductive, obstetric, and gynecologic health outcomes and sequelae.

Original languageEnglish (US)
Article number208
JournalFrontiers in Immunology
Volume9
Issue numberMAR
DOIs
StatePublished - Mar 2 2018

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Microbiota
Obstetrics
Uterus
Homeostasis
Bacteria
Health
Research
Population

Keywords

  • Endometrial cancer
  • Endometrium
  • Gynecologic and reproductive health
  • Host-microbe interactions
  • Infertility
  • Inflammation
  • Microbiome
  • Pathophysiology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Uterine microbiota : Residents, tourists, or invaders? / Baker, James M.; Chase, Dana M.; Herbst-Kralovetz, Melissa.

In: Frontiers in Immunology, Vol. 9, No. MAR, 208, 02.03.2018.

Research output: Contribution to journalReview article

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