The appropriateness of relying on the coefficient of determination (r 2) as a statistical metric for judging the predictability of human clearance (CL) based on interspecies animal data was assessed. An explicit mathematical expression was derived for r2 as a function of species body weight and the corresponding measured value of CL. The derived mathematical function demonstrated that r2 is numerically large in most instances. Simulations using random CL generated from a common combination of species of mouse, rat, and monkey resulted in an r2 of 0.75 as the minimum, and 0.95 and 0.98 at 50th and 75th percentiles, respectively, given that total CL values increase with increasing species body weight. Analysis of literature data also indicated that the prediction accuracy of human CL was not correlated with values of r2. Therefore, it is concluded that r 2 is a limited statistical measure when assessing allometric scaling for the purpose of predicting human CL.
ASJC Scopus subject areas
- Pharmaceutical Science