Utilization of pathway signatures to reveal distinct types of B lymphoma in the Eμ-myc model and human diffuse large B-cell lymphoma

Seiichi Mori, Rachel E. Rempel, Jeffrey T. Chang, Guang Yao, Anand S. Lagoo, Anil Potti, Andrea Bild, Joseph R. Nevins

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

The Eμ-myc transgenic mouse has provided a valuable model for the study of B-cell lymphoma. Making use of gene expression analysis and, in particular, expression signatures of cell signaling pathway activation, we now show that several forms of B lymphoma can be identified in the Eμ-myc mice associated with time of tumor onset. Furthermore, one form of Eμ-myc tumor with pre-B character is shown to resemble human Burkitt lymphoma, whereas others exhibit more differentiated B-cell characteristics and show similarity with human diffuse large B-cell lymphoma in the pattern of gene expression, as well as oncogenic pathway activation. Importantly, we show that signatures of oncogenic pathway activity provide further dissection of the spectrum of diffuse large B-cell lymphoma, identifying a subset of patients who have very poor prognosis and could benefit from more aggressive or novel therapeutic strategies. Taken together, these studies provide insight into the complexity of the oncogenic process and a novel strategy for dissecting the heterogeneity of B lymphoma.

Original languageEnglish (US)
Pages (from-to)8525-8534
Number of pages10
JournalCancer Research
Volume68
Issue number20
DOIs
StatePublished - Oct 15 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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