Utilizing hemodynamic delay and dispersion to detect fMRI signal change without auditory interference: The behavior interleaved gradients technique

G. F. Eden, J. E. Joseph, H. E. Brown, C. P. Brown, T. A. Zeffiro

Research output: Contribution to journalArticlepeer-review

140 Scopus citations

Abstract

A major problem associated with the use of functional magnetic resonance imaging (fMRI) is the attendant gradient noise, which causes undesirable auditory system stimulation. A method is presented here that delays data acquisition to a period immediately after task completion, utilizing the physiological delay and dispersion between neuronal activity and its resulting hemodynamic lag. Subjects performed finger movements with the gradients off, followed by a rest period with the gradients on. This resulted in task-related signals comparable to those obtained with concurrent task performance and image data acquisition. This behavior interleaved gradients technique may be particularly useful for the studies involving auditory stimulation or overt verbal responses.

Original languageEnglish (US)
Pages (from-to)13-20
Number of pages8
JournalMagnetic Resonance in Medicine
Volume41
Issue number1
DOIs
StatePublished - 1999

Keywords

  • Auditory
  • Behavior interleaved gradients
  • Motor cortex
  • Neuroimaging
  • Single-trial fMRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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