Uvaretin, a New Antitumor Agent from Uvaria acuminata (Annonaceae)

Jack R. Cole, Sterling J. Torrance, Richard M. Wiedhopf, Satish K. Arora, Robert B. Bates

Research output: Contribution to journalArticle

48 Scopus citations


The chloroform extract of Uvaria acuminata Oliv. has shown inhibitory activity against the P-388 lymphocytic leukemia test system of the National Cancer Institute. The major constituent of this extract was identified as the new 3′-benzyldihydrochalcone uvaretin, 1-[2,4-dihydroxy-3-(2-hydroxybenzyl)-6-methoxyphenyl]-3-phenyl-lpropanone (C23H22O5)· The structure was proven by x-ray crystallography and other methods.

Original languageEnglish (US)
Pages (from-to)1852-1855
Number of pages4
JournalJournal of Organic Chemistry
Issue number10
StatePublished - May 1 1976

ASJC Scopus subject areas

  • Organic Chemistry

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    Cole, J. R., Torrance, S. J., Wiedhopf, R. M., Arora, S. K., & Bates, R. B. (1976). Uvaretin, a New Antitumor Agent from Uvaria acuminata (Annonaceae). Journal of Organic Chemistry, 41(10), 1852-1855. https://doi.org/10.1021/jo00872a037