Vaccination with parenteral toxoid B protects hamsters against lethal challenge with toxin A-negative, toxin B-positive clostridium difficile but does not prevent colonization

Farida Siddiqui, Jennifer R. O'Connor, Kristin Nagaro, Adam Cheknis, Susan P. Sambol, Gayatri Vedantam, Dale N. Gerding, Stuart Johnson

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Toxin A has historically been regarded as the primary virulence determinant in Clostridium difficile infection, but naturally occurring toxin A-negative, toxin B-positive (A-/B+) C. difficile strains are known to be virulent. To determine the role of toxin B in these strains, we immunized hamsters with a toxoid prepared from purified toxin B to determine whether they would be protected from lethal challenge with an A-/B+ strain of C. difficile.

Original languageEnglish (US)
Pages (from-to)128-133
Number of pages6
JournalJournal of Infectious Diseases
Volume205
Issue number1
DOIs
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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