Vaccination with parenteral toxoid B protects hamsters against lethal challenge with toxin A-negative, toxin B-positive clostridium difficile but does not prevent colonization

Farida Siddiqui, Jennifer R. O'Connor, Kristin Nagaro, Adam Cheknis, Susan P. Sambol, Gayatri Vedantam, Dale N. Gerding, Stuart Johnson

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Toxin A has historically been regarded as the primary virulence determinant in Clostridium difficile infection, but naturally occurring toxin A-negative, toxin B-positive (A-/B+) C. difficile strains are known to be virulent. To determine the role of toxin B in these strains, we immunized hamsters with a toxoid prepared from purified toxin B to determine whether they would be protected from lethal challenge with an A-/B+ strain of C. difficile.

Original languageEnglish (US)
Pages (from-to)128-133
Number of pages6
JournalJournal of Infectious Diseases
Volume205
Issue number1
DOIs
StatePublished - Jan 1 2012

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Toxoids
Clostridium difficile
Cricetinae
Vaccination
Clostridium Infections
Virulence
Clostridium difficile toxB protein

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Vaccination with parenteral toxoid B protects hamsters against lethal challenge with toxin A-negative, toxin B-positive clostridium difficile but does not prevent colonization. / Siddiqui, Farida; O'Connor, Jennifer R.; Nagaro, Kristin; Cheknis, Adam; Sambol, Susan P.; Vedantam, Gayatri; Gerding, Dale N.; Johnson, Stuart.

In: Journal of Infectious Diseases, Vol. 205, No. 1, 01.01.2012, p. 128-133.

Research output: Contribution to journalArticle

Siddiqui, Farida ; O'Connor, Jennifer R. ; Nagaro, Kristin ; Cheknis, Adam ; Sambol, Susan P. ; Vedantam, Gayatri ; Gerding, Dale N. ; Johnson, Stuart. / Vaccination with parenteral toxoid B protects hamsters against lethal challenge with toxin A-negative, toxin B-positive clostridium difficile but does not prevent colonization. In: Journal of Infectious Diseases. 2012 ; Vol. 205, No. 1. pp. 128-133.
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