Validity of skin cancer malignancy reporting to the Organ Procurement Transplant Network: A cohort study

Transplant Skin Cancer Network (TSCN)

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: The Organ Procurement Transplant Network (OPTN) registry collects data on posttransplant malignancies in solid organ transplant recipients. Complete and accurate registry data on skin cancer is critical for research on epidemiology and interventions. Objective: The study goal was to determine the validity of Organ Procurement Transplant Network skin cancer data. Methods: This cohort study compared reporting of posttransplant squamous cell carcinoma (SCC) and malignant melanoma (MM) in OPTN to medical-record review-derived data from the Transplant Skin Cancer Network (TSCN) database. In total, 4934 organ transplant recipients from the TSCN database were linked to patient-level OPTN malignancy data. We calculated sensitivity, specificity, correct classification (CC), positive predictive value (PPV), and negative predictive value (NPV) for SCC and MM reporting in the OPTN database. Results: OPTN reporting for SCC (population prevalence 11%) had sensitivity 41%, specificity 99%, PPV 88%, NPV 93%, and CC 93%. OPTN reporting for MM (population prevalence 1%) had sensitivity 22%, specificity 100%, PPV 73%, NPV 99%, and CC 99%. Limitations: Only a subset of patients in the TSCN cohort had matched United Network for Organ Sharing cancer registry data for comparison. Conclusion: OPTN reporting had poor sensitivity but excellent specificity for SCC and MM. Dermatologists and transplant physicians are encouraged to improve the validity of OPTN skin cancer data through improved communication and reporting.

Original languageEnglish (US)
Pages (from-to)264-269
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume78
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

Tissue and Organ Procurement
Skin Neoplasms
Cohort Studies
Transplants
Neoplasms
Squamous Cell Carcinoma
Melanoma
Registries
Sensitivity and Specificity
Databases
Population

Keywords

  • cancer registry
  • melanoma
  • organ transplant
  • squamous cell carcinoma

ASJC Scopus subject areas

  • Dermatology

Cite this

Validity of skin cancer malignancy reporting to the Organ Procurement Transplant Network : A cohort study. / Transplant Skin Cancer Network (TSCN).

In: Journal of the American Academy of Dermatology, Vol. 78, No. 2, 01.02.2018, p. 264-269.

Research output: Contribution to journalArticle

@article{ec5285b2e2504899893276db3fabdde6,
title = "Validity of skin cancer malignancy reporting to the Organ Procurement Transplant Network: A cohort study",
abstract = "Background: The Organ Procurement Transplant Network (OPTN) registry collects data on posttransplant malignancies in solid organ transplant recipients. Complete and accurate registry data on skin cancer is critical for research on epidemiology and interventions. Objective: The study goal was to determine the validity of Organ Procurement Transplant Network skin cancer data. Methods: This cohort study compared reporting of posttransplant squamous cell carcinoma (SCC) and malignant melanoma (MM) in OPTN to medical-record review-derived data from the Transplant Skin Cancer Network (TSCN) database. In total, 4934 organ transplant recipients from the TSCN database were linked to patient-level OPTN malignancy data. We calculated sensitivity, specificity, correct classification (CC), positive predictive value (PPV), and negative predictive value (NPV) for SCC and MM reporting in the OPTN database. Results: OPTN reporting for SCC (population prevalence 11{\%}) had sensitivity 41{\%}, specificity 99{\%}, PPV 88{\%}, NPV 93{\%}, and CC 93{\%}. OPTN reporting for MM (population prevalence 1{\%}) had sensitivity 22{\%}, specificity 100{\%}, PPV 73{\%}, NPV 99{\%}, and CC 99{\%}. Limitations: Only a subset of patients in the TSCN cohort had matched United Network for Organ Sharing cancer registry data for comparison. Conclusion: OPTN reporting had poor sensitivity but excellent specificity for SCC and MM. Dermatologists and transplant physicians are encouraged to improve the validity of OPTN skin cancer data through improved communication and reporting.",
keywords = "cancer registry, melanoma, organ transplant, squamous cell carcinoma",
author = "{Transplant Skin Cancer Network (TSCN)} and Garrett, {Giorgia L.} and Yuan, {Joyce T.} and Shin, {Thuzar M.} and Arron, {Sarah T.} and Garrett, {Giorgia L.} and Oscar Colegio and Curiel, {Clara N} and Griffin, {John R.} and Huang, {Conway C.} and Anokhi Jambusaria and {Brian Jiang}, {Shang I.} and Leitenberger, {Justin J.} and Nijhawan, {Rajiv I.} and Shari Ochoa and Olasz, {Edit B.} and Clark Otley and Ortiz, {Arisa Elena} and Patel, {Vishal Anil} and Melissa Pugliano-Mauro and Schmults, {Chrysalyne D.} and Schram, {Sarah E.} and Thuzar Shin and Seaver Soon and Teresa Soriano and Divya Srivastava and Jennifer Stein and Kara Sternhell-Blackwell and Stan Taylor and Allison Vidimos and Peggy Wu and Arron, {Sarah T.}",
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TY - JOUR

T1 - Validity of skin cancer malignancy reporting to the Organ Procurement Transplant Network

T2 - A cohort study

AU - Transplant Skin Cancer Network (TSCN)

AU - Garrett, Giorgia L.

AU - Yuan, Joyce T.

AU - Shin, Thuzar M.

AU - Arron, Sarah T.

AU - Garrett, Giorgia L.

AU - Colegio, Oscar

AU - Curiel, Clara N

AU - Griffin, John R.

AU - Huang, Conway C.

AU - Jambusaria, Anokhi

AU - Brian Jiang, Shang I.

AU - Leitenberger, Justin J.

AU - Nijhawan, Rajiv I.

AU - Ochoa, Shari

AU - Olasz, Edit B.

AU - Otley, Clark

AU - Ortiz, Arisa Elena

AU - Patel, Vishal Anil

AU - Pugliano-Mauro, Melissa

AU - Schmults, Chrysalyne D.

AU - Schram, Sarah E.

AU - Shin, Thuzar

AU - Soon, Seaver

AU - Soriano, Teresa

AU - Srivastava, Divya

AU - Stein, Jennifer

AU - Sternhell-Blackwell, Kara

AU - Taylor, Stan

AU - Vidimos, Allison

AU - Wu, Peggy

AU - Arron, Sarah T.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background: The Organ Procurement Transplant Network (OPTN) registry collects data on posttransplant malignancies in solid organ transplant recipients. Complete and accurate registry data on skin cancer is critical for research on epidemiology and interventions. Objective: The study goal was to determine the validity of Organ Procurement Transplant Network skin cancer data. Methods: This cohort study compared reporting of posttransplant squamous cell carcinoma (SCC) and malignant melanoma (MM) in OPTN to medical-record review-derived data from the Transplant Skin Cancer Network (TSCN) database. In total, 4934 organ transplant recipients from the TSCN database were linked to patient-level OPTN malignancy data. We calculated sensitivity, specificity, correct classification (CC), positive predictive value (PPV), and negative predictive value (NPV) for SCC and MM reporting in the OPTN database. Results: OPTN reporting for SCC (population prevalence 11%) had sensitivity 41%, specificity 99%, PPV 88%, NPV 93%, and CC 93%. OPTN reporting for MM (population prevalence 1%) had sensitivity 22%, specificity 100%, PPV 73%, NPV 99%, and CC 99%. Limitations: Only a subset of patients in the TSCN cohort had matched United Network for Organ Sharing cancer registry data for comparison. Conclusion: OPTN reporting had poor sensitivity but excellent specificity for SCC and MM. Dermatologists and transplant physicians are encouraged to improve the validity of OPTN skin cancer data through improved communication and reporting.

AB - Background: The Organ Procurement Transplant Network (OPTN) registry collects data on posttransplant malignancies in solid organ transplant recipients. Complete and accurate registry data on skin cancer is critical for research on epidemiology and interventions. Objective: The study goal was to determine the validity of Organ Procurement Transplant Network skin cancer data. Methods: This cohort study compared reporting of posttransplant squamous cell carcinoma (SCC) and malignant melanoma (MM) in OPTN to medical-record review-derived data from the Transplant Skin Cancer Network (TSCN) database. In total, 4934 organ transplant recipients from the TSCN database were linked to patient-level OPTN malignancy data. We calculated sensitivity, specificity, correct classification (CC), positive predictive value (PPV), and negative predictive value (NPV) for SCC and MM reporting in the OPTN database. Results: OPTN reporting for SCC (population prevalence 11%) had sensitivity 41%, specificity 99%, PPV 88%, NPV 93%, and CC 93%. OPTN reporting for MM (population prevalence 1%) had sensitivity 22%, specificity 100%, PPV 73%, NPV 99%, and CC 99%. Limitations: Only a subset of patients in the TSCN cohort had matched United Network for Organ Sharing cancer registry data for comparison. Conclusion: OPTN reporting had poor sensitivity but excellent specificity for SCC and MM. Dermatologists and transplant physicians are encouraged to improve the validity of OPTN skin cancer data through improved communication and reporting.

KW - cancer registry

KW - melanoma

KW - organ transplant

KW - squamous cell carcinoma

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JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

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