Vanadium pentoxide (V2O5) induced mucin production by airway epithelium

Dongfang Yu, Dianne M. Walters, Lingxiang Zhu, Pak Kei Lee, Yin Chen

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Exposure to environmental pollutants has been linked to various airway diseases and disease exacerbations. Almost all chronic airway diseases uch as chronic obstructive pulmonary disease and asthma are aused by complicated interactions between gene and environment. ne of the major hallmarks of those diseases is airway mucus verproduction (MO). Excessive mucus causes airway obstruction and significantly increases morbidity and mortality. Metals are major components of environmental particulate matters (PM). Among them, vanadium has been suggested to play an important role in PM-induced mucin production. Vanadium pentoxide (V2O5) is the most common commercial source of vanadium, and it has been associated with occupational chronic bronchitis and asthma, both of which are MO diseases. However, the underlying mechanism is not entirely clear. In this study, we used both in vitro and in vivo models to demonstrate the robust inductions of mucin production by V2O5. Furthermore, the follow-up mechanistic study revealed a novel v-raf-1 murine leukemia viral oncogene homolog 1-IKK-NF-κB pathway that mediated V2O5- induced mucin production. Most interestingly, the reactive oxygen species and the classical mucin-inducing epidermal growth factor receptor (EGFR)-MAPK pathway appeared not to be involved in this process. Thus the V2O5-induced mucin production may represent a novel EGFR-MAPK-independent and environmental toxicant-associated MO model. Complete elucidation of the signaling pathway in this model will not only facilitate the development of the treatment for V2O5-associated occupational diseases but also advance our understanding on the EGFR-independent mucin production in other chronic airway diseases.

Original languageEnglish (US)
Pages (from-to)31-39
Number of pages9
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume301
Issue number1
DOIs
StatePublished - Jul 2011

Keywords

  • EGFR-independent
  • Nf-κb
  • Ros
  • V-raf-1 murine leukemia viral oncogene homolog 1

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology

Fingerprint Dive into the research topics of 'Vanadium pentoxide (V<sub>2</sub>O<sub>5</sub>) induced mucin production by airway epithelium'. Together they form a unique fingerprint.

  • Cite this