Vanishing bile duct syndrome in human immunodeficiency virus: Nevirapine hepatotoxicity revisited

Rajan Kochar, Moises I. Nevah, Frank J. Lukens, Michael B. Fallon, Victor I. Machicao

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Vanishing bile duct syndrome (VBDS) refers to a group of disorders characterized by prolonged cholestasis as a result of destruction and disappearance of intrahepatic bile ducts. Multiple etiologies have been indentified including infections, neoplastic disorders, autoimmune conditions and drugs. The natural history of this condition is variable and may involve resolution of cholestasis or progression with irreversible damage. VBDS is extremely rare in human immunodeficiency virus (HIV)-infected patients and anti-retroviral therapy has never been implicated as a cause. We encountered a young pregnant female with HIV and VBDS secondary to anti-retroviral therapy. Here, we report her clinical course and outcome.

Original languageEnglish (US)
Pages (from-to)3335-3338
Number of pages4
JournalWorld Journal of Gastroenterology
Volume16
Issue number26
DOIs
StatePublished - Jul 14 2010
Externally publishedYes

Keywords

  • Acquired immune deficiency syndrome
  • Cholangiopathy
  • Cholestasis
  • Drug-induced liver injury
  • Ductopenia
  • Vanishing bile duct syndrome

ASJC Scopus subject areas

  • Gastroenterology

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