Vaporising phase change ultrasound contrast agent in microvascular confinement

Shengtao Lin, Ge Zhang, Chee Hau Leow, Terry O Matsunaga, Meng Xing Tang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations

Abstract

The sub-micron perfluorocarbon-based phase change contrast agents (PCCAs) have shown great potential for imaging both microvasculature and tumour microenvironment. However the effect of geometrical confinement on the acoustic vaporisation has not been explored. We report the investigation of the difference in PCCA-produced contrast increase after activation with and without a microvessel confinement using in vitro experiment phantom. The results demonstrated that the acoustic vaporisation of PCCAs in the 200-micron cellulose tube was significantly different from that in the open environment, with contrast enhancement suppressed by up to several fold.

Original languageEnglish (US)
Title of host publication2016 IEEE International Ultrasonics Symposium, IUS 2016
PublisherIEEE Computer Society
Volume2016-November
ISBN (Electronic)9781467398978
DOIs
StatePublished - Nov 1 2016
Event2016 IEEE International Ultrasonics Symposium, IUS 2016 - Tours, France
Duration: Sep 18 2016Sep 21 2016

Other

Other2016 IEEE International Ultrasonics Symposium, IUS 2016
CountryFrance
CityTours
Period9/18/169/21/16

Keywords

  • acoustic vaporisation
  • microbubbles
  • microvessel
  • nanodroplets
  • phase change contrast agent
  • ultrasound

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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  • Cite this

    Lin, S., Zhang, G., Leow, C. H., Matsunaga, T. O., & Tang, M. X. (2016). Vaporising phase change ultrasound contrast agent in microvascular confinement. In 2016 IEEE International Ultrasonics Symposium, IUS 2016 (Vol. 2016-November). [7728724] IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2016.7728724