Vaporising phase change ultrasound contrast agent in microvascular confinement

Shengtao Lin; Ge Zhang; Chee Hau Leow; Terry O Matsunaga; Meng Xing Tang

doi:10.1109/ULTSYM.2016.7728724

Vaporising phase change ultrasound contrast agent in microvascular confinement

Shengtao Lin, Ge Zhang, Chee Hau Leow, Terry O Matsunaga, Meng Xing Tang

Medical Imaging

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

12 Scopus citations

Abstract

The sub-micron perfluorocarbon-based phase change contrast agents (PCCAs) have shown great potential for imaging both microvasculature and tumour microenvironment. However the effect of geometrical confinement on the acoustic vaporisation has not been explored. We report the investigation of the difference in PCCA-produced contrast increase after activation with and without a microvessel confinement using in vitro experiment phantom. The results demonstrated that the acoustic vaporisation of PCCAs in the 200-micron cellulose tube was significantly different from that in the open environment, with contrast enhancement suppressed by up to several fold.

Original language	English (US)
Title of host publication	2016 IEEE International Ultrasonics Symposium, IUS 2016
Publisher	IEEE Computer Society
Volume	2016-November
ISBN (Electronic)	9781467398978
DOIs	https://doi.org/10.1109/ULTSYM.2016.7728724
State	Published - Nov 1 2016
Event	2016 IEEE International Ultrasonics Symposium, IUS 2016 - Tours, France Duration: Sep 18 2016 → Sep 21 2016

Other

Other	2016 IEEE International Ultrasonics Symposium, IUS 2016
Country	France
City	Tours
Period	9/18/16 → 9/21/16

Keywords

acoustic vaporisation
microbubbles
microvessel
nanodroplets
phase change contrast agent
ultrasound

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2016.7728724

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Cite this

Lin, S, Zhang, G, Leow, CH, Matsunaga, TO & Tang, MX 2016, Vaporising phase change ultrasound contrast agent in microvascular confinement. in 2016 IEEE International Ultrasonics Symposium, IUS 2016. vol. 2016-November, 7728724, IEEE Computer Society, 2016 IEEE International Ultrasonics Symposium, IUS 2016, Tours, France, 9/18/16. https://doi.org/10.1109/ULTSYM.2016.7728724

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title = "Vaporising phase change ultrasound contrast agent in microvascular confinement",

abstract = "The sub-micron perfluorocarbon-based phase change contrast agents (PCCAs) have shown great potential for imaging both microvasculature and tumour microenvironment. However the effect of geometrical confinement on the acoustic vaporisation has not been explored. We report the investigation of the difference in PCCA-produced contrast increase after activation with and without a microvessel confinement using in vitro experiment phantom. The results demonstrated that the acoustic vaporisation of PCCAs in the 200-micron cellulose tube was significantly different from that in the open environment, with contrast enhancement suppressed by up to several fold.",

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AB - The sub-micron perfluorocarbon-based phase change contrast agents (PCCAs) have shown great potential for imaging both microvasculature and tumour microenvironment. However the effect of geometrical confinement on the acoustic vaporisation has not been explored. We report the investigation of the difference in PCCA-produced contrast increase after activation with and without a microvessel confinement using in vitro experiment phantom. The results demonstrated that the acoustic vaporisation of PCCAs in the 200-micron cellulose tube was significantly different from that in the open environment, with contrast enhancement suppressed by up to several fold.

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