Vaporization phenomena for ultrasound phase-change contrast agents assessed via high-speed optical microscopy

Paul S. Sheeran, Paul A. Dayton, Terry O. Matsunaga

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Many studies have proposed phase-change contrast agents (PCCAs) that vaporize to form bubbles ideal for contrast and cavitation. Understanding the phenomena involved with droplet vaporization to determine possible bioeffects will have a profound impact on designing agents to be effective in desired applications. In this study, we use ultra-high-speed microscopy to explore for the first time the vaporization phenomena of decafluorobutane (DFB) droplets. Results show that DFB droplets vaporize more rapidly than reported values for perfluoropentane droplets. As a result, bubbles from nanoscale droplets reach their final size within 200 ns, and are immediately subject to compression and rarefaction from the continuing pulse. DFB microscale droplets, in contrast, vaporize over the course of several microseconds, and tend to fuse with nearby bubbles. For very short pulses, the resulting bubbles show characteristic over-expansion and resonant oscillatory settling.

Original languageEnglish (US)
Title of host publication2013 IEEE International Ultrasonics Symposium, IUS 2013
Pages1841-1844
Number of pages4
DOIs
StatePublished - Dec 1 2013
Event2013 IEEE International Ultrasonics Symposium, IUS 2013 - Prague, Czech Republic
Duration: Jul 21 2013Jul 25 2013

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2013 IEEE International Ultrasonics Symposium, IUS 2013
CountryCzech Republic
CityPrague
Period7/21/137/25/13

Keywords

  • Acoustic droplet vaporization
  • High-speed imaging
  • Perfluorocarbon
  • Phase-change

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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    Sheeran, P. S., Dayton, P. A., & Matsunaga, T. O. (2013). Vaporization phenomena for ultrasound phase-change contrast agents assessed via high-speed optical microscopy. In 2013 IEEE International Ultrasonics Symposium, IUS 2013 (pp. 1841-1844). [6724795] (IEEE International Ultrasonics Symposium, IUS). https://doi.org/10.1109/ULTSYM.2013.0469