Variation and correlation in human fetal umbilical Doppler velocities with fetal breathing: Evidence of the cardiac-placental connection

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Abstract

Doppler velocity waveforms in the human fetal umbilical vein and artery were analyzed during episodes of fetal breathing. Heart rate, systolic and diastolic velocities were measured from the umbilical artery waveform. Diastolic velocity varied the most with a mean (± SD) coefficient of variation of 16.0% ± 5.0%. The coefficient of variation of systolic velocity was 7.8% ± 2.4% and of heart rate was 5.0% ± 1.8%. We also found that umbilical arterial flow was related to umbilical venous flow, implying an interdependence between fetal cardiovascular blood flow and placental blood flow. During breathing, venous flow varies because of changes in intrathoracic pressure in the fetus. This variation in umbillcal venous velocity may affect the umbilical arterial diastolic velocity through alterations in placental filling, and may affect the umbilical arterial systolic velocity through alterations in ventricular filling, which by the Frank-Starling mechanism changes stroke volume. The interdependency of umbilical venous and umbilical arterial blood flow velocities must be considered in the interpretation of the significance of umbilical artery Doopler velocity measurements.

Original languageEnglish (US)
Pages (from-to)1792-1796
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume163
Issue number6 PART 1
DOIs
StatePublished - 1990

Fingerprint

Umbilicus
Respiration
Umbilical Arteries
Heart Rate
Starlings
Umbilical Veins
Blood Flow Velocity
Fetal Blood
Stroke Volume
Fetus
Pressure

Keywords

  • Doopler ultrasonography
  • fetal breathing
  • Human fetal cardiovascular hemodynamics
  • umbilical artery
  • umbilical vein

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

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title = "Variation and correlation in human fetal umbilical Doppler velocities with fetal breathing: Evidence of the cardiac-placental connection",
abstract = "Doppler velocity waveforms in the human fetal umbilical vein and artery were analyzed during episodes of fetal breathing. Heart rate, systolic and diastolic velocities were measured from the umbilical artery waveform. Diastolic velocity varied the most with a mean (± SD) coefficient of variation of 16.0{\%} ± 5.0{\%}. The coefficient of variation of systolic velocity was 7.8{\%} ± 2.4{\%} and of heart rate was 5.0{\%} ± 1.8{\%}. We also found that umbilical arterial flow was related to umbilical venous flow, implying an interdependence between fetal cardiovascular blood flow and placental blood flow. During breathing, venous flow varies because of changes in intrathoracic pressure in the fetus. This variation in umbillcal venous velocity may affect the umbilical arterial diastolic velocity through alterations in placental filling, and may affect the umbilical arterial systolic velocity through alterations in ventricular filling, which by the Frank-Starling mechanism changes stroke volume. The interdependency of umbilical venous and umbilical arterial blood flow velocities must be considered in the interpretation of the significance of umbilical artery Doopler velocity measurements.",
keywords = "Doopler ultrasonography, fetal breathing, Human fetal cardiovascular hemodynamics, umbilical artery, umbilical vein",
author = "Indik, {Julia H} and Reed, {Kathryn L}",
year = "1990",
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journal = "American Journal of Obstetrics and Gynecology",
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TY - JOUR

T1 - Variation and correlation in human fetal umbilical Doppler velocities with fetal breathing

T2 - Evidence of the cardiac-placental connection

AU - Indik, Julia H

AU - Reed, Kathryn L

PY - 1990

Y1 - 1990

N2 - Doppler velocity waveforms in the human fetal umbilical vein and artery were analyzed during episodes of fetal breathing. Heart rate, systolic and diastolic velocities were measured from the umbilical artery waveform. Diastolic velocity varied the most with a mean (± SD) coefficient of variation of 16.0% ± 5.0%. The coefficient of variation of systolic velocity was 7.8% ± 2.4% and of heart rate was 5.0% ± 1.8%. We also found that umbilical arterial flow was related to umbilical venous flow, implying an interdependence between fetal cardiovascular blood flow and placental blood flow. During breathing, venous flow varies because of changes in intrathoracic pressure in the fetus. This variation in umbillcal venous velocity may affect the umbilical arterial diastolic velocity through alterations in placental filling, and may affect the umbilical arterial systolic velocity through alterations in ventricular filling, which by the Frank-Starling mechanism changes stroke volume. The interdependency of umbilical venous and umbilical arterial blood flow velocities must be considered in the interpretation of the significance of umbilical artery Doopler velocity measurements.

AB - Doppler velocity waveforms in the human fetal umbilical vein and artery were analyzed during episodes of fetal breathing. Heart rate, systolic and diastolic velocities were measured from the umbilical artery waveform. Diastolic velocity varied the most with a mean (± SD) coefficient of variation of 16.0% ± 5.0%. The coefficient of variation of systolic velocity was 7.8% ± 2.4% and of heart rate was 5.0% ± 1.8%. We also found that umbilical arterial flow was related to umbilical venous flow, implying an interdependence between fetal cardiovascular blood flow and placental blood flow. During breathing, venous flow varies because of changes in intrathoracic pressure in the fetus. This variation in umbillcal venous velocity may affect the umbilical arterial diastolic velocity through alterations in placental filling, and may affect the umbilical arterial systolic velocity through alterations in ventricular filling, which by the Frank-Starling mechanism changes stroke volume. The interdependency of umbilical venous and umbilical arterial blood flow velocities must be considered in the interpretation of the significance of umbilical artery Doopler velocity measurements.

KW - Doopler ultrasonography

KW - fetal breathing

KW - Human fetal cardiovascular hemodynamics

KW - umbilical artery

KW - umbilical vein

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