Vasoactive intestinal peptide (VIP) receptors in the canine gastrointestinal tract

R. P. Zimmerman, T. S. Gates, C. R. Mantyh, S. R. Vigna, C. G. Boehmer, P. W. Mantyh

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Vasoactive intestinal peptide (VIP) is a putative neurotransmitter in both the brain and peripheral tissues. To define possible target tissues of VIP we have used quantitative receptor autoradiography to localize and quantify the distribution of 125I-VIP receptor binding sites in the canine gastrointestinal tract. While the distribution of VIP binding sites was different for each segment examined, specific VIP binding sites were localized to the mucosa, the muscularis mucosa, the smooth muscle of submucosal arterioles, lymph nodules, and the circular and longitudinal smooth muscle of the muscularis externa. These results identify putative target tissues of VIP action in the canine gastrointestinal tract. In correlation with physiological data, VIP sites appear to be involved in the regulation of a variety of gastrointestinal functions including epithelial ion transport, gastric secretion, hemodynamic regulation, immune response, esophageal, gastric and intestinal motility.

Original languageEnglish (US)
Pages (from-to)1241-1253
Number of pages13
JournalPeptides
Volume9
Issue number6
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

Keywords

  • Autoradiography
  • Canine gastrointestinal tract
  • Receptors
  • VIP
  • Vasoactive intestinal peptide

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Vasoactive intestinal peptide (VIP) receptors in the canine gastrointestinal tract'. Together they form a unique fingerprint.

  • Cite this

    Zimmerman, R. P., Gates, T. S., Mantyh, C. R., Vigna, S. R., Boehmer, C. G., & Mantyh, P. W. (1988). Vasoactive intestinal peptide (VIP) receptors in the canine gastrointestinal tract. Peptides, 9(6), 1241-1253. https://doi.org/10.1016/0196-9781(88)90188-X