Vemurafenib treatment for patients with locally advanced, unresectable stage IIIC or metastatic melanoma and activating exon 15 BRAF mutations other than V600E

Sigrun Hallmeyer, Rene Gonzalez, David H. Lawson, Lee D Cranmer, Gerald P. Linette, Igor Puzanov, Bret Taback, C. Lance Cowey, Antoni Ribas, Gregory A. Daniels, Timothy Moore, Geoffrey T. Gibney, Hussein Tawbi, Eric Whitman, Geraldine Lee, Yong Mun, Shiyao Liu, Omid Hamid

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

BRAF mutations are found in ~ 50% of metastatic melanomas, most commonly in codon V600. Vemurafenib improves progression-free survival and overall survival in patients with advanced BRAFV600E-mutated melanoma. The results of a descriptive study evaluating vemurafenib in patients with advanced melanoma harbouring BRAF mutations other than V600E are reported. Eligible patients with stage IIIC or IV melanoma and non-V600E BRAF mutations received vemurafenib (960 mg, twice daily). End points included investigator-assessed best overall response rate (primary), time to response, duration of response, progression-free survival, overall survival and safety. Planned (V600K vs. non-V600K mutations) subgroup analyses were carried out. Thirty-one patients were enrolled; 13 (42%) had V600K mutations and 18 (58%) had other mutations. Investigator-assessed confirmed that the best overall response rate was 23% (95% confidence interval=10-41%) in the overall population, and was similar between patients with V600K mutations (23%; 95% confidence interval=5-54%) versus other mutations (22%; 95% confidence interval=6-48%). Responses were observed in patients with V600K (n=3), V600E2 (n=1), V600R (n=1), L597S (n=1) and D594G (n=1) mutations. No new safety signals were reported. Vemurafenib showed activity in patients with advanced melanoma with rarer BRAF mutations.

Original languageEnglish (US)
Pages (from-to)585-590
Number of pages6
JournalMelanoma Research
Volume27
Issue number6
DOIs
Publication statusPublished - 2017

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Keywords

  • DNA mutational analysis
  • Melanoma
  • Vemurafenib

ASJC Scopus subject areas

  • Oncology
  • Dermatology
  • Cancer Research

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