Viral metabolic reprogramming in marine ecosystems

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Marine viruses often contain host-derived metabolic genes (i.e., auxiliary metabolic genes; AMGs), which are hypothesized to increase viral replication by augmenting key steps in host metabolism. Currently described AMGs encompass a wide variety of metabolic functions, including amino acid and carbohydrate metabolism, energy production, and iron-sulfur cluster assembly and modification, and their community-wide gene content and abundance vary as a function of environmental conditions. Here, we describe different AMGs classes, their hypothesized role in redirecting host carbon metabolism, and their ecological importance. Focusing on metagenomic ocean surveys, we propose a new model where a suite of phage-encoded genes activate host pathways that respond rapidly to environmental cues, presumably resulting in rapid changes to host metabolic flux for phage production.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalCurrent Opinion in Microbiology
Volume31
DOIs
StatePublished - Jun 1 2016

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology

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